biochemistry III
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- An alternatiave pathway, the ______, operates to varying extents in different cells and tissues. The role of this pathway is primarily ____ rather than catabolic.
-
Pentose Phosephate Pathway
Anabolic - The Pentose Phosphate pathway has two primary functions:
-
1. To provide NADPH (nicotinamide adenine dinucleotide Phosphate) for reductive biosynthesis
2. To provide ribose-5-phosphate (5 carbon sugar) for nucleotide and nucleic acid biosynthesis - In addition to providing NADPH for reductive syn. and ribose-5-phosphate, the Pentose pathway operates to:
-
1. metabolize diatary pentose sugars
2. in plants acts as the reverse to the carbon fixation process. - Pentose Phosphate pathway is an alternative to glucose oxidation and produces the following precursers:
-
NADPH
Ribose-5-P
Erythrose-4-P
Other sugar Phosphates -
Anabolic means:
Catabolic: -
biosynthesis
Breakdown to produce energy - What are the major sites of production for cholesterol?
-
1. LIver
2. adrenal cortex
3. Gonads (sex hormones)
4. Small intestine - All cell types can syn cholesterol but derive it from __ secreted by the __
-
plasma lipoprotein
liver
adn intestine. -
If the liver adn intestine
do not provide enough __, then __ syn. of cholesterol (27C compound) is activated in other cells -
plasma lipoprotiens
DE NOVO - What is the major control point in cholesterol syn?
- HMG-CaA Reductase
- cholestyramine can
- lower cholesterol by lowerign hepatic pool which causes the production of more LDL receptors
- ATherosclerosis is
-
1. infection damages lining of artery
2. cholesterol attaches to lining
3. congealed blood covers chol
4.prevents chol plaque to be removed adn build up plaque on artery
5. lead to heart attack