Onc - genetics
Terms
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- c-myc oncogene
- burkitt's lymphoma
- bcl-2 oncogene
- follicular and undifferentiated lymphomas (inhibits apoptosis)
- erb-B2 oncogene
- breast, ovarian, and gastric carcinomas
- ras oncogene
- colon cancer
- L-myc oncogene
- lung tumor
- N-myc oncogene
- neruoblastoma
- ret oncogene
- multiple endocrine neoplasia (MEN I and II)
- Oncogene
- gain of function
- tumor supressor gene
- loss of function - must loose both alleles
- Rb tumor supressor gene
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- chrom 13q
- retenoblastoma, osteosarcoma - BRCA1 and 2 tumor supressor gene
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- chrom 17q and 13q
- breast and ovarian cancer - p53 tumor supressor gene
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- chrom 17p
- most human cancers, li-fraumeni syndrome - APC tumor supressor gene
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- chrom 5q
- colorectal cancer - WT1 tumor supressor gene
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- chrom 11q
- wilms' tumor - NF1 tumor supressor gene
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- chrom 17q
- neurofibromatosis type 1 - NF2 tumor supressor gene
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- chrom 22q
- neurofibromatosis type 2 - DPC tumor supressor gene
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- chrom 18q
- pancreatic cancer - DCC tumor supressor gene
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- chrom 18q
- colon cancer - Tumor marker
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- not 1o tool for diagnosis
- can confirm diagnosis, or monitor recurrance and response to therapy - PSA tumor marker
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- prostate specific antigen
- prostatic carcinoma
- used for screening - CEA tumor marker
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- carcinomembryonic antigen
- nonspecific, produced by 70% of colorectal and pancreatic cancers
- gastric and breast too - alpha-fetoprotein tumor marker
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- normally made by fetus
- hepatocellular carcinomas
- nonseminomatous germ cell cancer of the testis - beta-hCG tumor marker
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- hydatidiform moles
- choriocarcinomas
- gestational trophoblastic tumors - CA-125 tumor marker
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- ovarian
- maligant epithelial tumors - S-100 tumor marker
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- melanoma
- nerual tumors
- astrocytomas - alkaline phosphate tumor marker
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- metastases to bone
- obstructive bilary disease
- paget's disease of bone - bombesin tumor marker
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- neuroblastoma
- lung and gastric cancer - TRAP tumor marker
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- tartrate-resident acid phosphate
- hairy cell leukemia - a beta-cell neoplasm - t(9,22) - philadelphia chromosome
- CML
- t(8,14)
- burkitt's lymphoma
- t(14,18)
- follicular lymphoma (bcl-2 activation)
- t(15,17)
- M3 type of AML (responsive to all-trans retinoic acid)
- t(11,22)
- Ewing's sarcoma
- t(11,14)
- mantle cell lymphoma