Pathology Respiratory System
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- What tumor-derived hormones are secreted in paraneoplastic syndrome associated with bronchogenic carcinoma?
- Parathyroid-like polypeptide (hypercalcemia); ACTH-producing tumor (overstimulation of adrenals-->cushings syndrome); ADH-producing (water retention)
- Sarcoidosis can affect any organ, but what does it affect especially, according to lecture (according to carranza⬦.blah blah blah)
- Especially Lungs, thoracic/neck lymph nodes, the skin, salivary glands, and lacrimal gland (dryness)
- Which chronic lung disease is caused by inhalation of fumes, dust, or particulate matter (inorganic)?
- Pneumoconioses
- What is usually the etiology of URTI's (common cold)?
- Viruses (ie rhinoviruses, coronavirus, RSV, parainfluenza, etc.
- Moderate hypertension, angina pectoris, congestive heart failure are what ASA type?
- III
- Chronic Hypersensitivity pneumonitis is _______ ________, as opposed to acute which is mediated by antigen-antibody complexes.
- Cell mediated
- What disease is associated with amyloidosis and recurrent pneumonias?
- Bronchiectasis
- What is this process: Airless lung parenchyma due to incomplete expansion of lungs or collapse of previously infiltrated lung
- Atelectasis
- Bacterial URTI's are not as common as viral, but when present exhibit what characteristics?
- PMN's and exudate formation; whitish yellow membranes in throat
- T or F: a patient with latent TB is not infectious
- TRUE
- The type of emphysema caused by Alpha 1-antitrypsin deficiency is called _________ emphysema.
- Panacinar
- Dyspnea, Cachexia, Barrel Chest, Cor Pulmonale, Congestive Heart Failure are clinical signs of what disease?
- Emphysema
- Bronchitis, Emphysema, or Both: Minimal Sputum
- Emphysema
- "Barrel Chest" is a result of what?
- attempt to increase ventilation
- Coccidiomycosis, Aspergillosis, or Zygomycosis: Deep fungal lung disease
- All of them (that better not have tricked you)
- Coccidiomycosis, Aspergillosis, or Zygomycosis: Especially in diabetics
- Zygomycosis
- Bronchitis, Emphysema, or Both: Severe Dyspnea
- Emphysema (Puffer=dyspnea)
- The _______ cavity is the space between viseral pleura and parietal pleura (separated by thin layer of fluid)
- Pleural
- Cor pulmonale causes _________ heart failure due to __________.
- Right-sided; Pulmonary hypertension caused by lung disease
- T or F: Chronic Bronchitis at times is not easily distinguished from Emphysema.
- True; sometimes they go hand in hand
- What is the most significant congenital respiratory disease?
- Tracheo-esophageal fistula
- What are four examples of congenital respiratory diseases?
- Tracheo-esophageal fistula, Bronchiogenic cysts, hypoplasia, vascular anomalies
- What is the name of the disease caused by URTI's?
- common cold
- Who is most susceptible to deep fungal lung diseases?
- Immunosuppressed, AIDS pts, uncontrolled diabetics, transplant pts, etc.
- Bronchitis, Emphysema, or Both: Hypoxia, Cyanosis, polycythemia (increased rd blood cells)
- Bronchitis
- What 3 types of atelectasis are there?
- Deficiency of surfactant; External compression of lung; resorption of air in lung, distal to an obstruction
- What is the most common complication of chronic bronchitis?
- Bronchiectasis
- In obstructive lung disease, Total lung capacity/forced vital capacity is _______ to ________.
- Normal to Increased
- Coccidiomycosis, Aspergillosis, or Zygomycosis: Often in a hospital setting
- Aspergillosis
- T or F: Tumors can be associated with bronchiectasis
- TRUE
- T or F: Asthma is a reversible airway obstruction.
- TRUE
- In obstructive lung disease, there is a _________ in expiratory flow rate.
- Decrease
- Cavitary lesions filled with pus.
- Lung Abscess
- T or F: Cystic fibrosis can be associated with bronchiectasis
- TRUE
- ________ obstruction (in obstructive lung disease) is due to narrowing of airway (what disease) or loss of elastic recoil (what disease).
- Expiratory; asthma; emphysema
- What is the key element of the massive lung fibrosis that causes pneumoconioses?
- Alveolar Macrophages
- In restrictive lung disease, total lung capacity is __________.
- decreased
- T or F: A patient with Bronchiectasis presents with bronchi (and/or bronchioli) filled with mucopurulent material; this mucous can be cleared by coughing.
- First statement true, second statement false
- Restrictive lung disease is due primarily to either _________ abnormalities or __________ damage.
- chest wall; parenchymal
- Bronchitis, Emphysema, or Both: Weight loss
- Emphysema (cachexia)
- What two body systems does the ASA (MED) classification emphasize?
- Cardiovascular and Respiratory
- A particle that is less than ______ microns in size can enter alveoli, contributing to what disease?
- 5; Pneumoconioses
- What 2 components of the bronchial wall are primarily involved in asthma? (undergo hyperplasia)
- Mucous glands (goblet cells); Smooth muscle
- T or F: Chronic inflammation is part of asthma.
- TRUE
- What Antibody is involved in extrinsic asthma?
- IgE
- T or F: Sarcoidosis can affect any organ, not just the lungs.
- TRUE
- What ASA classification would a patient with mild to moderate systemic disease that does not interfere with day-to-day activity?
- ASA II
- What are the 3 main Middle Respiratory tract infections?
- 1. Croup; 2. Epiglottitis, 3. Bronchiolitis
- What bronchodilators are used to treat asthma?
- Beta2-agonists; theophyline
- What clinical significance does multiple asthma medications have?
- More medications means more severe asthma
- Is Asthma a restrictive or obstructive lung disease?
- Usually Obstructive
- Is asthma considered acute or chronic?
- Acute (although the underlying process is more chronic)
- What disease is associated with low grade fever, malaise, fatigue, and clubbing of the fingers?
- Bronchiectasis
- What types of medications might patients with bronchitis or emphysema be on? List 5
- Bronchodilators, corticosteroids, diuretics, alveolar surfactants, antibiotics
- Greater than __ emergency room visits in the past year are a risk factor for treating a patient with asthma.
- 3
- 3 general types of lesions of the pleura:
- Inflammatory, traumatic, neoplastic
- Use of greater than __ beta-agonist canisters per month is a risk factor for asthma patients.
- 2
- T or F: current use of systemic corticosteroids is a risk factor for asthma pts.
- TRUE
- Bronchitis, Emphysema, or Both: Peribronchial fibrosis
- Bronchitis
- Sepsis, shock, trauma, pneumonia, toxic lung injury, aspiration of fluids, and blood transfusions can all cause what disease?
- Acute respiratory distress syndrome
- What bacteria predominantly causes Lung abscess?
- S. Aureus
- Which MRTI is characterized by: acute viral illnes of larynx, especially affects ages 3-5 yrs., loud cough, barking seal (like chase in the mornings)
- Croup
- What is the major asthma medication which can cause complications with long term use?
- Corticosteroids
- T or F: Anthracosis increases incidence of Tuberculosis.
- TRUE
- What four complications can long term use of corticosteroids have?
- Osteoporosis, immunosuppression, addisonian crisis (secondary adrenal insufficiency), diabetes
- What fungal disease do all our professors like to talk about since it is widespread in the midwest?
- Histoplasmosis
- Increased responsiveness of bronchial tree to various stimuli is ________.
- asthma
- If a dental patient with asthma has had no attacks for several years, they are what ASA/MED?
- II
- If a dental patient with asthma has occasional attacks managed by bronchodilators they are what ASA?
- III
- T or F: In Cor Pulmonale, The Right Ventricle hypertrophies due to congestion in the lungs.
- TRUE
- If a dental patient with asthma has many/severe attacks they are what ASA?
- IV
- What % of patients with sarcoidosis have elevated ACE (angiotensin Converting Enzyme)?
- 60 % (another percentage baby)
- T or F: Aspirin is involved in Intrinsic asthma.
- TRUE
- Mild hypertension, some forms of diabetes melitus are characteristic of what ASA type?
- II
- What medications should you avoid prescribing to asthma patients?
- Beta blockers, aspirin, sulfites
- T or F: Croup is extremely life-threatening.
- FALSE
- ________ abscesses have a fibrous capsule
- chronic
- What are the three major chronic obstructive pulmonary diseases (COPD)?
- Emphysema, Chronic Bronchitis, Bronchiectasis
- T or F: Many times COPD is a combination of chronic bronchitis and emphysema, not just pinned down to one systemic problem.
- TRUE
- Why do patients with bronchiectasis have clubbing of the fingers?
- It is related to chronic hypoxia.
- T or F: All patients affected with Acute Respiratory Distress Syndrome die during the acute stage.
- False. 70% die during this stage, but the remainder progress to a chronic stage, where 10% may survive, and 20% eventually die from interstitial fibrosis
- T or F: COPD is a reversible condition
- FALSE
- T or F: Most histoplasmosis infections go on to become chronic.
- False; most are acute and then resolve
- Among patients with COPD in the US, the vast majority have __________ (14 million) and the remainder have __________ (2 million)
- Chronic Bronchitis; Emphysema
- Name the 5 factors that are considered in susceptibility to Pneumoconioses.
- 1. Size/shape of particle (<5 microns); 2. Composition of particles; 3. Duration of exposure; 4. Patients clearance mechanism; 5. Other irritants (ie smoking)
- What is the only acute, restrictive lung disease?
- Acute respiratory distress syndrome
- Acute Respiratory Distress Syndrome is caused by a mechanism of either 1. Injury to the _________ _______ in pulmonary capillaries or 2. Injury to the ________ _________ _______.
- 1. Endothelial cells; 2. Alveolar lining cells
- What disease: Enlargement of airspaces distal to terminal bronchioles; destruction of alveolar walls; loss of elastic recoil; collapse of unsupported, enlarged air spaces on expiration; obstruction on expiration
- Emphysema
- Name the ASA class: Severe systemic disease that limits activity but not incapacitating
- ASA III
- T or F: Silicosis can lead to bronchogenic carcinoma.
- TRUE
- What is the characteristic difference of air sacs between healthy air sacs and air sacs with emphysema?
- Emphysema: weakened and collapsed air sacs with Excess mucous
- This disease was first widely recognized during the vietnam war (Da Nang Lung).
- Acute respiratory distress syndrome
- What are lung abscesses a complication of?
- Staphylococcal pneumonia; aspiration of foreign material (swallowing a crown, poor dental hygiene, etc.)
- Bronchitis, Emphysema, or Both: Pulmonary hypertension
- Both
- What is the major cause of emphysema?
- Cigarettes
- T or F: It is necessary to consult with a physician prior to treating a ASA II patient.
- FALSE
- In extremely rare cases (1%) what can cause emphysema?
- hereditary alpha1-antitrypsin deficiency (which protect the tissue from leukocyte proteases)
- In the Protease-antiprotease mechanism of emphysema, what 2 things does smoking do?
- 1. Inhibits antielastase; 2. favors recruitment of leukocytes and release of elastase (causing elastic damage to the tissue)
- Which MRTI is characterized by: acute, severe, life-threatening disease, presents as a child w/ fever +/- sore throat, clinical triad of drooling, dysphagia, distress
- Epiglottitis
- Other than the protease-antiprotease mechanism, what else does smoking do to cause emphysema?
- Oxidant/antioxidant imbalance (free radicals released, induce cell damage)
- The type of emphysema caused by smokers is called _________ emphysema.
- Centrilobular
- Which type of bronchogenic carcinoma has the worst prognosis, most aggressive, and not usually amenable to surgery?
- Small Cell (oat cell)
- Bronchitis, Emphysema, or Both: Frequent Upper Respiratory infections
- Bronchitis
- Name the types of Pleural Lesions:
- Mesothelioma, Pleural effusions and plueritis, Pneumothorax, Hemothorax, Chylothorax
- What disease: Excessive production of tracheobronchial mucous causing cough.
- Chronic Bronchitis
- What 3 diseases included in COPD (chronic obstructive pulmonary disease)?
- Emphysema, Chronic Bronchitis, Bronchiectasis (just a reminder)
- What disease: erodes bronchial wall, eric-smelling sputum, chest pain, weight loss, chronic cough, fever, clubbing of fingers and toes
- Lung Abscess *note, bronchiectasis also has clubbing of toes--the difference here is eroding of bronchial wall. Bronchiectasis is permanent dilatation of bronchial wall.
- N2O (increases/supresses) pH as a stimulus to respiration, because N2O has a high O2 content.
- supresses
- T or F: ASA III patients can withstand most dental procedures with appropriate modifications.
- TRUE
- Anthracosis, Silicosis, or Asbestosis, all three, or none: Increased risk of TB
- Anthracosis and Silicosis
- _____ % of Chronic Bronchitis cases are caused by _________.
- 90%; Smoking (I know we all love percentages)
- What organism causes Epiglottitis?
- Haemophilus Influenzae
- T or F: N2O can diffuse into closed spaces
- TRUE
- Bronchitis, Emphysema, or Both: Acute disease
- Neither (trick question!)
- What are the risk factors for contracting histoplasmosis (other than living in this hell hole we call omaha⬦.j/k)
- exposure to soil contaminated with bird poo, preexisting COPD, compromised immunity
- What disease: Thickening of bronchial walls, mucous gland hyperplasia, chronic inflammation, fibrosis, mucous plugging.
- Chronic Bronchitis
- The presence of transudate in the pleural space is called ________
- hydrothorax; caused by CHF and Left-sided heart failure especially
- T or F: Chronic Bronchitis results in Restriction.
- False; leads to obstruction
- What are the main differences in the pathways for chronic bronchitis and emphysema?
- Bronchitis: bronchiolar injury, hypersecretion of mucous; emphysema: destruction of alveolar walls early (bronchitis does it later)
- What ASA type is a patient with COPD and NO congestive heart failure?
- ASA/MED III
- What ASA type is a patient with COPD WITH congestive heart failure?
- ASA/MED IV
- Which acute disease exhibits severe dyspnea, cyanosis, and hypoxia?
- Acute respiratory distress syndrome
- One of the main characteristics (underlined in the notes) of chronic Bronchitis is ________.
- Fibrosis
- What is ectasia?
- dilatation or distension of hollow organs
- Anthracosis, Silicosis, or Asbestosis, all three, or none: Can lead to mesothelioma
- Asbestosis (this is the #1 characteristic of asbestosis)
- What disease: Permanent dilatation of bronchi, can be secondary to persisting infection or obstruction
- Bronchiectasis
- T or F: Asthma is more common in females.
- FALSE (males 2:1)
- What process takes place in pulmonary fibrosis or tuberculosis?
- Cavitation
- What is the first step in treatment for bronchitis and emphysema?
- Quit smoking
- ________ occurs as a result of an exudate (protein rich)
- Pleuritis
- The two chronic restrictive lung diseases caused by occupational/environmental exposure are: 1.____, 2._________
- Hypersensitivity Pneumonitis; Pneumoconioses (ie asbestosis)
- In this disease, fibrin is deposited along damaged alveolar lining , which leads to diffuse alveolar damage.
- What is Acute respiratory distress syndrome? (jeopardy style baby)
- Anthracosis, Silicosis, or Asbestosis, all three, or none: increases risk of cancer 5 fold
- Asbestosis
- Chronic Restrictive lung diseases are diseases of _________ ________.
- Lung parenchyma
- Anthracosis, Silicosis, or Asbestosis, all three, or none: runs a benign course
- Anthracosis
- What term means: Labored Breathing
- Dyspnea
- T or F: Now epiglottitis is more prevalent in children than adults.
- False. Other way around.
- 90% of all lung cancers are caused by smoking (150,000 deaths/yr). What are the other 10% caused by? (hint-variety of things)
- Radon (radioactive gas=2nd leading cause--.20,000 deaths/yr); Air pollution; Radiation exposure; Asbestos exposure; Nickel and chromate exposure
- The end result of chronic restrictive lung diseases is _________.
- Diffuse pulmonary fibrosis
- Anthracosis, Silicosis, or Asbestosis, all three, or none: shows pleural plaques
- Asbestosis
- T or F: Chronic Bronchitis gives you the "pink puffer."
- False; gives you "Blue Bloater" (B for Bronchitis, Blue Bloater)
- Anthracosis, Silicosis, or Asbestosis, all three, or none: Leads to Fibrosis
- All Three
- What causes pleural effusion?
- Microbial infection, cancer, pulmonary infarction, viral pleuritis
- Which chronic restrictive lung disease has no known cause?
- Idiopathic pulmonary fibrosis
- Histoplasmosis infection symptoms include: fever, chills, weight loss, cough (with/without) mucus or pus
- WITH
- In asbestosis, what sets off a fibrogenic reaction?
- Macrophages ingesting an asbestos fiber
- What immune cells are primarily involved in asthma?
- mast cells
- Neutrophil/complement defects (humoral defects) result in increased incidence of ___________ ________.
- Bacterial pneumonia
- What disease invovles extrinsic allergic alveolitis caused by exposure to organic dust?
- Hypersensitivity Pneumonitis
- Cell-mediated immune defects result in increased incidence of (intracellular/extracelluar) ___________.
- Intracellular parasites (ie TB, HSV, pneumocystis carinii)
- What are the two types of asthma?
- Extrinsic and Intrinsic
- What MRTI is characterized by: acute infectious disease of lower respiratory tract (bronchi/bronchioles, not alveoli), mostly in young infants 2-24 mos.,
- Bronchiolitis
- What disease presents commonly following URTI, absent splenic function, chills, pleuritic chest pain, productive cough.
- Pneumonia
- What ways can pneumonia be spread?
- Inhalation of pathogens, aspiration of infection, aspiration of gastric contents, hematongenous spread (IV, septic emboli)
- What disease: Multi-system granulomatous disease of unknown etiology (presumably immune mediated)
- Sarcoidosis
- What are the possible complications of pneumonia?
- Abscess formation; Plueritis, empyema (collection of pus); fibrosis--> chronic Dx
- T or F: in a patient older than age 40, in the absence of systemic infection, lung complications should be assumed it is cancer until proven otherwise.
- TRUE
- What term means: Physican wasting with loss of weight and musche mass caused by disease
- Cachexia
- T or F: Emphysema gives you the "pink puffer."
- True (emphysema=pink puffer)
- What is the definition of Pneumonia?
- Any infection in the lung (acute or chronic)
- Pneumonia is of Bacterial, viral, or fungal origin?
- Any of the above.
- In Asthma, which is more difficult, expiration or inspiration?
- Expiration
- T or F: Pneumoconioses is caused by exposure to organic dust particles.
- False; inorganic particles (organic--Hypersensitivity Pneumonitis)
- What are the 2 main subclasses of pneumonia?
- Lobar Pneumonia and Bronchopneumonia
- ________ asthma is associated with young-onset asthma.
- Extrinsic
- What is main cause of Bronchiolitis?
- Viral infection (80%--esp. respiratory synctial virus)
- Bronchopneumonia or Lobar Pneumonia: Consolidation of multiple respiratory units surrounding individual bronchial branches
- Bronchopneumonia
- Bronchopneumonia or Lobar Pneumonia: Consolidation of entire Lobe of Lung
- Lobar Pneumonia
- What are the 2 main pathways of pathogenesis for Acute Respiratory Distress Syndrome?
- Damage to alveolar lining cells or damage to alveolar capillary endothelium--leads to interstitial edema, high protein exudation (hyaline membranes)
- What treatment difference is there for bronchitis?
- Use bronchodilators and antibiotics.
- What organisms cause community acquired acute pneumonias?
- Haemophilus Influenzae; Moraxella catarrhalis; Staph Aureus; Klebsiella Pneumoniae; Legionella Pneumoniae
- What organism causes Pneumococcus?
- Streptococcus pneumoniae
- How can histoplasosis be diagnosed?
- sputum test, chest x-ray, biopsy of granulomatous tissue, complement fixation, urinary antigen test, immunodiffusion test
- What organisms cause community acquired atypical pneumonias?
- Mycoplasma Pneumoniae, Chlamidia sp., Viruses
- What type of asthma is associated with Type I hypersenistivity, allergens, atopic dermatitis and hay fever?
- Extrinsic
- T or F: Hypersensitivity pneumonitis is only an acute disease.
- False. It can also be a chronic disease.
- What is the death rate for SARS?
- 10% die
- Give an example of a community acquired atypical pneumonia caused by a virus.
- SARS
- What immune related chronic restrictive lung disease affects blacks 10:1 and women 2:1?
- Sarcoidosis
- What organism causes nosocomial pneumonia (according to lecture notes)?
- Pseudomonas Aeruginosa
- What is the primary cause for aspiration pneumonia?
- Markedly debilitated; unconscious patients; abscesses frequent
- Fibrothorax, Pneumothorax, Empyema, Hemothorax, or chylothorax: encasement of lungs with fibrous tissue that obliterates pleural cavity.
- Fibrothorax
- T or F: Lung cancer usually has a poor prognosis with a 5 yr survival rate of 10-15%.
- TRUE
- Cytomegalovirus primarily affects who?
- Immunosuppressed (AIDS), bone marrow transplant
- Pneumocystis pneumonia affects who?
- Immunosuppressed (AIDS)
- What organism causes tuberculosis?
- Mycobacteria Tuberculosis (causes chronic bacterial infection)
- What chronic lung disease is associated with caseating granulomatous inflammation?
- Tuberculosis
- T or F: Anthracosis usually leads to bronchogenic carcinoma.
- False; Most=benign course
- How is histoplasmosis treated?
- Antifungals
- What types of cells are associated with TB?
- epitheliod macrophages, multinucleated giant cells, lymphocytes
- approximately how many of the world's population are infected with TB?
- one-third
- T or F: Intrinsic asthma is immune-mediated.
- False
- What disease: purulent cough, dyspnea, hypoxia, cyanosis, peribronchial fibrosis, pulmonary hypertension, cor pulmonale, congestive heart failure.
- Chronic Bronchitis
- Fibrothorax, Pneumothorax, Empyema, Hemothorax, or chylothorax: Entry of air or gas into pleural cavity; may cause atelectasis, compression, collapse of lung.
- Pneumothorax (spontaneous vs trauma)
- What is the "Ghon Complex"?
- associated with localized lung inflammation in primary tuberculosis
- Acute hypersensitivity pneumonitis is of _______ onset and is mediated (or affected) by _________ ________.
- Sudden; antigen-antibody Complexes
- T or F: Primary TB usually heals spontaneously
- TRUE
- Define Consolidation as it refers to the lungs.
- Process of becoming solid (ie when lung becomes firm as air spaces are filled with exudate in pneumonia)
- What treatment is there for the rare form of emphysema?
- alpha 1-antitrypsin infusion
- T or F: In primary TB, viable organisms can still persist after healing and calcification
- TRUE
- T or F: Bronchiolitis usually resolves in 7-10 days.
- TRUE
- T or F: Histoplasmosis ususally responds poorly to antifungal meds.
- False; responds well
- The "ghon Complex" forms in which part of the lung and enlarges which lymph nodes?
- lower part of upper lobe, upper part of lower lobe (right in the middle); enlarges hilar lymph nodes
- T or F: Sarcoidosis exhibits caseating granulomas
- False; exhibit non-caseating granulomas
- Anthracosis, Silicosis, or Asbestosis, all three, or none: Increased risk of bronchogenic carcinoma
- Silicosis (maybe asbestosis too, but mesothelioma is the characteristic sign of asbestosis
- Granulomas in TB can produce cavities in the lungs which can cause hemoptysis. What is hemoptysis?
- coughing up blood
- T or F: The primary TB infection is more damaging than the secondary infection.
- False (other way around)
- What disease: non-specific mild pulmonary disease, low grade fever, 95% undiagnosed, ghon complex
- Primary TB
- What disease: Non-productive cough, low grade fever, malaise, night sweats, weight loss, hemoptysis
- Secondary TB
- One of the MAIN causes (that he underlined) of INTRINSIC asthma is _______
- Psychological stress
- What can be seen in a sputum test for TB?
- Acid fast bacilli
- How long after a Mantoux skin test should you be examined?
- 48-72 hrs.
- What Middle Respiratory Tract Tumor did we mention in class? (only one)
- SCCA (squamous cell carcinoma) of Larynx
- What are 3 specific examples of Pneumoconioses?
- 1. Coal worker's lung (anthracosis); 2. Silicosis; 3. Asbestosis
- T or F: the erythema around the indurated area of a PPD test is measured.
- False. Only the induration is measured (normal = <10 mm)
- What potential complication arises from using N2O sedation on a patient with emphysema?
- They can be dependent on LOW O2 levels as a primary stimulant to respiration; N2O has high concentration of O2 so it can lead to cease of respiration.
- T or F: After treating histoplasmosis, fibrotic changes may still remain.
- TRUE
- Fibrothorax, Pneumothorax, Empyema, Hemothorax, or chylothorax: Pockets of pus surrounded by fibrous tissue; caused by infection that spreads from the lung.
- Empyema
- Bronchitis, Emphysema, or Both: Productive cough
- Bronchitis
- What can be done in the dental office to prevent an attack of dyspnea during treatment?
- Treat in semi-upright position; always have inhaler
- T or F: Asthma is more common in children.
- TRUE. 10% of children get it, while 5% of adults get it.
- What disease: widespread hematogenous seeding of bacteria; numerous granulomas in lungs or other organs (ie spleen)
- Miliary TB
- T or F: Sarcoidosis is typically a fatal disease.
- False; 10% mortality, 70% spontaneous recovery, 50% asymptomatic
- T or F: Disseminated TB can cause granulomas on pluera (causing pleuritis) and extrapulmonary TB
- TRUE
- Where are the most common sites of metastasis of lung cancers?
- Brain and Liver mostly, occasionaly bone (mandible), rarely oral soft tissue
- Premature infants commonly have respiratory problems due to insufficient pulmonary __________.
- surfactant
- What is the main cause of SCCA of the larynx?
- Smoking and chronic alcohol use
- What is by far the most common type of lung cancer?
- Bronchiogenic Carcinoma (90-95% of lung cancers)
- Two of the causes of Hypersensitivity Pneumonitis (as stated in the notes) are: __________ Lung and _______ _________ Lung.
- Farmer's Lung (moldy hay/grain); Pigeon Breeder's Lung (pigeon serum protein in droppings)
- T or F: Pulmonary Histoplasmosis progression to Disseminated Histoplasmosis is common.
- FALSE; happens, but rarely
- If N2O diffuses into large gas-filled blebs in patients with COPD, what can happen?
- They can rupture
- Fibrothorax, Pneumothorax, Empyema, Hemothorax, or chylothorax: Collection of blood in space between chest wall and lung (pleural cavity).
- Hemothorax (trauma vs. rupture of intrathoracic aortic aneurysm)
- List the 4 types of Bronchiogenic carcinomas.
- 1. SCCA (30%) 2. Adenocarcinoma (30%) 3. Large Cell undifferentiated (10%) 4. Small Cell (oat cell-20%)
- Coccidiomycosis, Aspergillosis, or Zygomycosis: Southwest
- Coccidiomycosis
- What type of lung cancer arises from the terminal bronchioles?
- Bronchioalveolar cancer
- What is a type of lung cancer that is a neuroendocrine tumor of low malignancy?
- Carcinoid
- What ASA type(s) is it mandatory to consult with the physician first?
- IV (III is wise, but not necessary)
- What type of lung cancer is associated with asbestos exposure, takes 25-40 yrs to develop, is pluera-derived, and has a poor prognosis?
- Mesothelioma
- What disease: persisten hoarseness, change in voice, stridor (high pitched crowing sound), rare under age 40
- SCCA of larynx
- Bronchitis, Emphysema, or Both: Cor Pulmonale
- Both
- What do small (oat) cells arise from?
- Neuroendocrine cells
- T or F: Metastatic lung tumors are more common than primary lung tumors (single site)
- TRUE
- What is the treatment and survival rate for SCCA of the larynx?
- Radiation w/ or w/out surgery; 75% survival rate if early Dx.
- What type of hormones do small (oat) cell (bronchogenic carcinoma) express?
- polypeptide hormones
- Fibrothorax, Pneumothorax, Empyema, Hemothorax, or chylothorax: Presence of lymphatic fluid in pleural space; secondary to leakage/obstruction of thoracic duct or main tributaries
- Chylothorax (causes: lymphoma, surgical trauma)
- What chronic lung disease is associated with elevated ACE?
- Sarcoidosis