Pharm2.2
Terms
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- Griseofulvin
- bind to mitotic spindles of fungi and prevents division
- Amphotericin B
- bind to sterol on cell membrane
- Clotrimazole - Lotrimin
- membrane leakage during cell division
- Amox. and Clavulinate - Augmentin
-
A-inhibit bact. pro. cell synthesis
C-beta lactamase inhib. - Amoxicillin
- bind to penicillin binding protein and inhibit bact. pro synthesis in cell wall
- Cephalexin - Keflex
- binds to penicillin binding pro and inhibit bact. pro synthesis in cell wall
- Azithromycin - Zithromax
- inhib. pro synthesis by binding to 50s bact. ribosome
- Tetracycline
- inhibit bact. pro. synthesis by interfering with 30S ribosome
- Gentamicin
- bind to 30S and 50S ribosomal subunits and interfere with pro synthesis
- Sulfamethoxazole
- competitive antagonist of para-aminobenzoic acid (PABA) which is used by bact. to synthesize folic acid
- Sulfamethoxazole with Trimethoprim - Bactrim or Septra
- trimethoprim interferes with folic acid at sucessive step giving a synergistic effect
- Ciprofloxacin - Cipro
- inhibit DNA gyrase (uncoils DNA) and influence nucleic acid metabolism
- Erythropoietin
- gene regulation via growth factor receptor activation in the bone marrow
- Cyclosporine - Sandimmune
- blocks intracellular T cell signalling causing inhib. production of IL-2 by T-cells
- Etancercept - Enbrel
- inactivates TNF alpha (tumor necrosis factor)
- Acyclovir - Zovirax
- nucleoside analog (inhib. viral DNA polymerase)
- Zidovudine - Retrovir
- thymidine analog (chain termination)
- Immune Globulins
- interfere with virus penetrating cells
- Interferons
-
? mb one of:
inhib. viral penetration
inhib. viral peptide elongation
degrade viral mRNA - Chloroquine
- accumulate in food vacuole of parasite and prevents detox of heme metabolism (toxic)
- Quinine and Quinidine
- inhibit nucleic acid synthesis in parasites
- Metronidazole
- cytotoxic effect on pro and DNA via specific enzyme
- Tetrahydrozoline - Visine
- vasoconstriction
- Azelastine - Optivar
- blocks H1 receptor sites
- Ketorolac - Acular
- cyclooxygenase inhibitor
- Tobramycin - Tobrex
- inhib. bacterial pro. synthesis
- Timolol - Timoptic
- blocks ocular ep - decreasing aqueous humour
- Mupirocin - Bactroban
- inhibits bact. pro. synthesis
- Ketoconazole - Nizarol
- inhibits sterol synthesis
- Tretinoin - Retin A
- decrease hyperkeratinization, increases epidermal thickness and decreases collagen synthesis
- Isoretinoin - Accutane
- decreases hyperkeratinization, sebaceous gland, sebus and propionibacterium acne (bact.)