PDA I Exam 1
Terms
- A-methyltyrosine (metyrosine)
-
Inhibits tyrosine hydroxylase
Which will inhibit synthesis of NE and E
-
Acetylcholine (Miochol)
-
Cholinergic Agonist
Parasympathomimetic
- Amphetamine
-
Stimulates NE release
Reverse NE transport
Powerful A and B actions
- Arecoline
-
Cholinergic Agonist
Parasympathomimetic
- Atenolol
-
B1 antagonist
- Atropine
- Muscarinic Antagonist
-
Bethanechol (Myotonichol)
-
Cholinergic Agonist
Parasympathomimetic
- Botox
-
Blocks release of ACh
- Carbachol (Miostat)
-
Cholinergic Agonist
Parasympathomimetic
-
Carbamic Acid Derivatives
-
Indirect Cholinergic Agonist
Blocks ACh from binding AChE by binding to AChE itself.
Reversible
- Clonidine
-
A2 Agonist
- Cocaine
-
Blocks NE transportor (NET)
Increases NE in synapse
- Dobutamine
-
B1 agonist
- Echothiophate
-
Cholinergic Agonist
Irreversible Inhibitor
- Edrophonium
-
Cholinergic Agonist
Reversible Inhibitor
- Ephedrine
-
Enhances release of NE
A and B agonist
Bronchodilator
-
Hemicholinium (HC-3)
- Blocks transport of choline
- Isoproterenol
- A2 Agonist
- Malathion
-
Cholinergic Agonist
Irreversible Inhibitor
-
Methacholine (Provocholine)
-
Cholinergic Agonist
Parasympathomimetic
-
Methyldopa (Aldomet)
-
Inhibits AADC from decarboxylating Dopa
Will inhibit synthesis of NE and E
It decarbs and hydros itself to become a false transmitter
- Muscarine
-
Cholinergic Agonist
Parasympathomimetic
- Neostigmine
-
AChE inhibitor
Enhance Cholinergic tranmission
Cholinergic Agonist
Reversible Inhibitor
- Nicotine
-
Cholinergic Agonist
Parasympathomimetic
- Organophosphates
-
Indirect Cholinergic Agonist
Through Hydrolysis- formation of phosphorylated enzyme on AChE. Phosphate ion remains on active site and ACh cannot bind.
Irreversible
- Parathion
-
Cholinergic Agonist
Irreversible Inhibitor
- Phenylephrine
-
A1 Agonist
- Pilocarpine (Salagen)
-
Cholinergic Agonist
Parasympathomimetic
- Prazosin
-
A1 antagonist
- Pyridostigmine
-
Cholinergic Agonist
Reversible Inhibitor
- Reserpine
-
Depletes NE by blocking VMAT
- Terbutaline
-
B2 agonist
-
Trimethapham and Hexamethonium
-
Nicotinic Antagonists
- Tyramine
-
False Transmitter
Displaces NE
- Vesamichol
- Blocks the transport of ACh
- Yohimbine
-
A2 antagonist