Endocrine drugs
Terms
undefined, object
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Treatment of pheochromocytoma?
class? -
phenoxybenzamine
alpha blocker - Treatment of SIADH?
- demeclocycline
- Blockers of 5'-deiodinase (3)
-
propranolol
glucocorticoids
propylthiouracil - What is a goitrogen?
- a chemical that causes goiter (i.e. a hypertrophied thyroid gland)
-
Goitrogens:
inhibitors of iodine transport (2)
inhibitors of binding/coupling (2) -
thiocyanate
perchlorate
propylthiouracil
methimazole - Calcitonin can be used therapeutically for.... (2)
-
osteoporosis
Paget's
and anything else involved with hypercalcemia - Important treatment for hyperkalemia
- Give insulin
- Treatment for Conn's syndrome
- spironolactone
-
Treatment of diabetes insipidus:
central (1)
nephrogenic (3) -
desmopressin
hydrochlorothiazide
indomethacin
amiloride -
Treatment of carcinoid syndrome
whate else is this agent used to treat (2) -
octreotide
intractable diarrhea
GI bleeding - Another name for GnRH
- gonadorelin
-
Leuprolide indications:
pulsatile use (1)
continuous use (3) -
infertility
(acts as a GnRH agonist)
prostrate cancer
uterine fibroids
endometriosus
(acts as a GnRH antagonist) -
Bromocriptine MOA?
use? (2) -
dopamine receptor agonist
hyperprolactinemia
acromegaly - Oxcytocin use? (2)
-
induce labor
decrease postpartum bleeding
dinoprostone is also used for the former - name two uterine relaxants and their MOA
-
ritodrine
terbutaline
B2 agonists - What are menotropins and what are they used for?
-
partially degraded FSH and LH
used to induce follicle maturation in infertile women - ACTH analog?
- cosyntropin
- Name three agents used to treat hypothyroidism
-
levothyroxine (T4)
Liothyronine
Liotrix (combo of the above two) - Iodine use? (2)
-
pre-ope shrink of thyroid
thyroid storm -
Propylthiouracil and methimazile MOA?
use?
which one can inhibit peripheral conversion of T4 to T3? -
inhibit peroxidase enzymes
hyperthyroidism
propylthiouracil -
most serious SE of propylthiouracil?
why is it preferred in pregnancy and why? -
agranulocytosis
PTU is more protien bond and has less chance to cross placenta or milk to induce hypothyroidim - Treatment for severe tetany as well as severe hyperkalemia
- calcium gluconate
-
Disphosphonates:
Name two?
MOA?
use? -
etidronate disodium
pamidronate disodium
bind hydroxyapatie crystals and stalls bone resorption
Pagets
osteoporosis and others - Treatment for bronchial asthma
- beclmethasone
-
ketoconazole MOA?
use? (2) -
inhibits steroid synthesis
polycystic ovarian syndrome
hirsutism -
Name 4 sulfonylureas?
MOA?
use? -
tolbutamide chlopropamide
glyburide glypizide
stimulate B cells to secrete insulin
NIDDM - SE of 1st generation sulfonylureas (tolbutamide, chlorpropamide)
- disulfiram like effects
-
Metformin use?
SE? -
anti-hyperglycemic
(unknowm mechanism)
lactic acidosis - acarbose and miglitol MOA?
- a-glucosidase inhibitors in brush border decreases glucose absorption
-
Glitazones: (pioglitazone, rosiglitazone, troglitazone)
MOA? - increase the sensitivity of tissues to insulin by binding PPARS