clotting
Terms
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- thrombin
- final protease to be generated, cleaves fibrinogen to fibrin
- thrombin-extrinsic
- tissue factor exposed
- thrombin-intrinsic
- on the surface of platelets or other cells
- decrease in pgi2
- cause platelets to become reactive-recruit platelets and adhere to matrix
- white thrombus (arterial)
- forms in rapid arterial circulation and is made of platelets and fibrin
- red thrombus (venous)
- forms in injured vein and is made of fibrin, RBC's, and fewer platelets
- platelets adhere to
- vWF and collagen when pgi2 is low
- thrombin is and does...
-
serine protease, increases intracellular calcium and platelet shape change
**releases adp and txa2 - thrombin receptor
- PAR1, proteolytic process
- heparin
- polysaccharide, stimulates natural inhibitors of coagulant proteases
- heparin MOA
- binds to antithrombin III and makes conformational change (inhibits thrombin)
- reverse heparin
- protamine sulfate
- warfarin
- similar to vitamin k, forms abnormal clotting factors that do not work
- drug interactions-warfarin
- phenylbutazone, phenytoin, barbiturates, aspirin
- reverse warfarin
- give vitamin k1 (phytonadione)
- aspirin
- blocks conversion of arachidonic acid to thromboxane A2
- ticlopidine and clopidogrel
- inhibits ADP induced platelet aggregation
- abciximab
- mouse monoclonal antibody, directed against GP IIb-IIIa receptor
- eptifibatide
- peptide derived from rattlesnake venom, directed against GP IIb-IIIa receptor
- streptokinase
- dissolves clots by binding to plasminogen and converts to plasmin
- urokinase
- dissolves clots by binding to plasminogen and converts to plasmin
- tissue plasminogen activator (tpa)
- converts plasminogen to plasmin, which lyses fibrin clots