Acute Inflammation
Terms
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- Vascular Permeability due to
- mediated (chemical response), non mediated (necrosis of endothelium from toxins and physical agents)
- Abscess
- mass of necrotic tissue, with dead and viable neutrophils, suspended in the fluid products of tissue breakdown brought about by neutrophil enzymes
- Lipoxygenase pathway produce
- LTC4, LTD4, LTE4 which causes vasoconstriction and increase permeability in venules
- Functio Laesa
- Loss of function
- Fluid component function
- dilute/buffer toxins, diffusion of mediators, immunoglobulins
- Kinins
- peptide derived from plasma protein, activated by hageman factor, cleaves prekallikrein to kallikrein which stimulates kininogen to from bradykinin, mediate increase vascular permeability, cause pain and activates complement system
- Composition of acute inflammatory exudate
- fluid, fibrin, polymorphs, macrophage, lymphocyte
- A2, thromboxane
- aggregate platelets and causes vascular constriction
- Plasmin
- actiave hageman factor, complement system, lyses fibrin
- Critical step in activation of endothelium
- expression of cell adhesion molecules
- C3a
- liberate histamine
- Cytokines
- cell adhesion, prostacyclin synthesis, PAF synthesis, acute phase protein synthesis by liver, stimulation of fibroblast, neutrophil attraction
- nitric oxide
- mediate cell/bacterial killing, vascular dilation
- Chronic abscess
- fibrosis around actue abscess
- C3b
- opsonises bacteria
- Acute abscess
- scarring
- Hageman factor activated
- in contact with collagen
- PGI2, prostacyclin
- inhibits platelet aggregation, dilates vessels
- Why do macrophage outlive neutrophils
- oxidative metabolism
- Weal
- zone of oedema due to fluid exudation
- LTB4
- leucocyte adhesion
- PAF
- vasoconstriction, increase vascular permeability, platelet aggregation,stimulate synthesis of arachidonic acid
- Dolor
- Pain
- Neutrophil Polymorphs originate from
- Myeloid precursors
- Tumour
- Swelling
- Vascular events
- dilatation of vessels, loss of axial flow,formation of inflammatory exudate
- C345
- chemotactic for neutrophils
- Prostaglandins and leukotrines derived from
- arachidonic acid
- C5a
- liberate histamine,, chemotactic to neutrophils, induce endothelial cell adhesion molecules
- 3 Composition of Exudate
- serous, purulent, fibrinous
- Chemokines
- secreted by leukocytes and endothelial cells. Bind locally to extracelluoar matrix and heparin sulphate proteoglycans
- Stable prostaglandins, PGE2,PGF2alpha,PGD2
- vasodilation, increase vascular permeability
- Duffy antigen receptor for chemokines
- remove chemokines
- Flare
- Red, irregular surrounding zone, arteriolar dilatation
- Flush
- Dull red line, capillary dilatation
- Calor
- Heat
- Rubor
- Redness