Mild Cognitive Impairment (MCI)
Terms
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- Mild cognitive impairment (MCI) is a transition phase between normal ______ and _________.
- aging; dementia
- the term MCI was coined by Peterson et al (99,01); describes individuals with c/o and objective evidence of _____ impairment but no evidence of ________.
- memory; dementia
- Past terms related to ______ have included malignant senescent forgetfulness, age-assoc. memory imp., late-life forgetfulness, age-assoc. cog. decline, age-related cog. decline, mild cog. decline, mild neurocog. disorder.
- MCI
- Past concepts for phenomena similar to MCI have had inconsistent inclusion criteria. This has impeded understanding of e______, p______, conversion rates to ______, and estimates of i________ and p__________
- etiology, prognosis, dementia; incidence and prevalence
- dx criteria of MCI: (1)______ complaints, pref. corroborated by informant; (2) impaired _____ fx on testing (controlled for age & ed.); (3)preserved general ______ ______; (4) intact activities of ______ ______; (5) no evidence of _________
- memory; memory; cognitive fx/intell. ability; daily living; dementia
- differential: more minor complaints/difficulties seen in normal aging, while there is greater interference with _____ and _____ in dementia (as well as other changes in cognitive functioning)
- memory; ADLs
- some evidence suggests that combining the __-___ S___ Exam and the Cognitive Capacity Screening Exam shows good sensitivity and specificity in IDing those with MCI who later convert to ________
- MMSE; Alz. Dementia
- NP evals must screen for these factors which may account for memory difficulties(name 3):
- depression, anxiety, chronic pain
- Some studies have shown that pts. with MCI had markedly lower scores on smell ID tests than did normals; may be useful in a battery but be aware that this test may be _____ but not _____ to MCI.
- sensitive; specific
- neuroimaging and neuropathology studies suggest some atrophy of the ______ in pts. with MCI, which was predictive of conversion to ______ ______. Neuropath. studies on individuals with MCI have shown evidence of n_________ t_________s.
- hippocampus, Alz. Dementia; neurofibrillary tangles
- prevalence of MCI in non-institutionalized individuals may be up to _______ times that of AD
- four
- predictors of MCI progression to AD include _________ atrophy and ________ susceptibility
- hippocampal, genetic