onc 9
Terms
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a - Follicular Hyperplasia
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a -
Paracortical Hyperplasia - cirlce is Paracortical
hyperplasia - line is to a germinal center or follicle -
a - Sinus Histiocytosis - Arrows outline lymph node sinuses filled with histiocytes
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a - Hodgkin’s Lymphoma - Nodular Sclerosis Subtype - w/ Sclerotic bands (fibrous tissue)
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a - Hodgkin’s Lymphoma - lymphocyte predominant
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a - Hodgkin’s Lymphoma - mixed cellularity
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a - Hodgkin’s Lymphoma - lymphocyte depleted reticular
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a - Hodgkin’s Lymphoma - lymphocyte depleted diffuse fibrosis
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a - Hodgkin’s Lymphoma - nodular sclerosis
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a - Reed-Sternberg Cell
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a - hodgkins lymphoma - Lymphocyte predominant
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a - Hodgkin’s Lymphoma - mixed cellularity
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a - Hodgkin’s Lymphoma - Lymphocyte depleted
- Follicular Hyperplasia
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- Proliferation of B’s
- Increased need for Ab production
- enlargement of germinal centers
- neck nodes in Strep throat - Paracortical Hyperplasia
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- Proliferation of T's
- Increased need for cell-mediated immunity
- Expansion of paracortical regions
– neck nodes in mono - sinus Histiocytosis
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- Prolif of macrophages
- stimulation of Ag-presenting cells
- Expansion of subcapsular / medullary sinuses
– LNs draining a carcinoma - Hodgkins - epi
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- High peak in 20s then later
- ass w/ EBV and HIV - Hodgkins diagnosis
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- Reed Sternberg cells!
- Lymphocytes, eosinophils, histiocytes, fibroblasts
- most have lymphodenopathy above the diaphram - Nodular Sclerosis Hodgkins
- Most common
- Mixed Cellularity Hodgkins
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- Less good prognosis
- Greater tendency to be extranodal - Lymphocyte Predominant Hodgkins
- Best prognosis
- Lymphocyte Depleted Hodgkins
- Worst prognosis
- Hodgkins - determining prognosis
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- LASSS
- LDH AGE STAGE SITE STATUS - Hodgkins treatment
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- Stage I, II - RADIATION + chemotherapy
- Stage III, IV do CHEMOTHERAPY + radiation
- drugs are ABVD adriamycin, bleomycin, vinblastine, dacarbazine