Goljan High Yield
Terms
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- Dz associated w/ anti-acetylcholine receptor?
- myasthemia gravis
- Dz assoc. w/ anti-centromere Ab?
- CREST Sx 60% and PSS 10%
- Dz assoc. w/ anti-gliadin Ab?
- Celiac Dz (95%)
- Dz assoc. w/ anti-glomerular basement membrane?
- Goodpasture Sx (90%)
- Against what Ab is anti-GBM directed to?
- Collagen Type IV
- What Dz is assoc. w/ anti-islet cel Abs?
- Type I DM
- What Dz is assoc. w/ anti-microsomal Abs?
-
Hashimotos (97%)
autoimmune hepatitis (70%) - Dz. assoc. w/ anti-mitochondrial Abs?
- primary biliary cirrhosis (90-100%)
- Dz. assoc w/ C-ANCA?
- Wegner's Granulnomatosis
- Dz. assoc. w/ P-ANCA?
-
Polyarteritis Nodosa (PAN)
and Hep B associated to PAN - Dz. assoc. w/ anti-parietal cell Abs?
- Pernicious Anemia
- Dz. assoc. w/ intrinsic factor Abs?
-
Pernicous Anemia Type I (Ab to B12 prevent binding to IF)
Type II (Ab to IF or complex) - Dz. assoc. w/ anti-smooth muscle Abs?
- Autoimmune Hepatitis (70%)
- Dz. assoc. w/ anti-thyroglobulin Ab?
-
Hashimoto (85%)
Grave's (30%) - What Dz is associated w/ myasthemia gravis?
- thymoma (60%)
- HLA relationship of hemochromatosis?
- A3
- HLA relationship of Myasthemia Gravis?
- B8
- HLA relationship of Celiac Dz?
- B8 and DR3
- HLA relationship of Ankylosing Spondylitis?
- B27
- HLA relationship of Multiple Sclerosis?
- DR2
- HLA relationship of Type I DM?
- DR3 and DR4
- HLA relationship of Rheumatoid Arthritis?
- DR4
- What is the MCC of Autoimmune Hemolytic Anemia?
- Warm IgG Lupus
- 2nd MCC of Hemolytic Anemia?
- Drug Induced Hemolytic Anemia
- What two drugs used for HT for pregnancy?
- Hydralazine, Methyl-Dopa
- Hydralazine causes?
- Drug Induced Lupus
- MC drug that causes drug-induced Lupus?
- Procainamide
- What Ab is made against alpha-methyl dopa?
-
IgG
G is for Gravida - What Ab is made against Quinide?
- IgM
- What does IgG activate?
- Macrophages to become active
- What does IgM activate?
-
Complement System
MAC
C1-C9 - What disease causes leukemoid reaction?
-
B. pertussis
Scares Pediatricians!!!
>60,000 WBCs - Mononucleosis caused by ------>
- EBV
- What cell does EBV infect?
- B-Cell
- What is the marker (receptor) for EBV, B-cells?
- CD21
- What drug induces atypical lymphocytes?
- phenytoin
- MOA of Phenytoin?
- Blocks intestinal Conjugase
- What drug causes macrocytic anemia and atypycal lymph?
- Phenytoin
- Where does EBV hide for the rest of the life of the patient?
-
Salivary Glands
Kissing Disease - What test is diagnostic for Mononucleosis?
- Anti Heterophile Antibody
- What diseases cause eosinophilia?
-
Strongyloides
Malaria
Type I Yes
whipworm - MCC of Bud-Chiari Sx?
- polycytemia vera
- Age of ALL?
- 0-15
- Age of AML?
-
15-40
40-60 - Age of CLL?
- >60
- Age of CML?
- 40-60
- MC overall Leukemia? ------->
- CLL
- Characteristic of CLL?
- MC generalized non-tender lymphadenopathy >60y ?
- MC Leukemia >60yo?
- CLL
- Where does CLL metastisize to?
- lymph nodes
-
49 y.o. 150,000 WBC
1% myeloblasts (<30% blasts) generalized lymphadenopathy - CML
- Translocation of CML?
- t9;22 of abl gene
-
49 y.o. 150,000 WBC
1% myeloblasts (<30%) generalized lymphadenopathy - CML
- What gene/chromosome is important in CML?
- Philadelphia Chromosome 22
- What translocation is seen in CML?
- t9;22
- What is the gene in t9;22?
- bcr-abl gene
- What two tests are used to Dx CML?
-
Philadelphia Chromosome (+) and LAP (low level)
LAP = leukocyte alkaline phosphatase not absorbed by malignant cells - What do is the Dx when you see a tear drop cell?
- Agnogenic Myeloid Metaplasia
- Pt. 4yo, w/ generalized non-tender lymphadenopathy, sternal tenderness, hepatosplenomegaly, fever, normocytic anemia, 50,000 WBCs abnormal appearing cells
- ALL
- What antigen is use to detect ALL?
- CALLA
- What does CALLA detect?
- B-cells CD10
- Pt. 65 yo man, hepatosplenomegalic, 90,000 WBC smudge cells, also pt. has hypogammaglobulinemia
- CLL age gives it away
- What leukemia has auer rods in it?
- AML
- What leukemia has lots of auer rods?
- Acute Promyelocytic Leukemia (M3)
- What are the four/five myeloproliferative dz?
-
1. polycythemia vera
2. chronic myelogenous leukemia
3. adenogenic myeloid metaplasia
4. essential thrombocytemia
myelodysplastic Sx - What are the four H's of polycythemia vera?
-
1) Hyperviscosity
2) Hypervolemia
3) Histaminemia
4) Hyperuricemia - What is the Dx of a patient that complains of itching after taking a shower hot or cold?
- Polycythemia ruba vera
- What is the translocation of Burkitt's Lymphoma?
- t8;14
- What is responsible for Burkitt's Lymphoma?
- EBV
- What do you see in the pathology slides for Burkitt's?
- Starry Sky Appearance
- What are the three K for Burkitt's?
-
Kid 8yo
8 is for translocation 8;14
blacK
C-Myc - What are the stars in Burkitt's?
- Macrophages
- United States where is Burkitt's Located?
- Abdomen (Peyer's Patches, Paraortic Lymph nodes), Testicle also
- African Burkitt's lymphoma MC location?
- Jaw
- What two tissues are resistant to cancer infection?
- Cartilage and Elastic Vessels
- Pat. w/ plaque like lesions w/ inflamatory cells in epidermis?
-
Neoplastic epidermis cells Helper T-Cells
Mycosis Fungoides - What is a helper T-cell malignancy that involves skin?
- Mycosis Fungoides
- What cell is involved in Mycosis Fungoides?
- Sezary Body
- What is a sezary body?
- Helper T-cell seen in plasma of pat. w/ Mycosis Fungoides
- What substance is secreted and produced by Gastic Adenocarcinoma (Linitis Plastica)?
- Mucin Producer
- What is the appearance of the stomach in linitis plastica?
-
diffusely inflitrative (thickened appearance)
mucosa and muscularis produced rigid thick, leather-bottle gastric wall