3rd year clinical 3sct----
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- 1. Useful markers in HCL ?
- 1.TRAP, CD11/20/103
- 2. Useful marker in PLL ?
- FMC7
- PLL are usually of a B/T cell origin
- B
- What is M protein
- IgG/IgA
- t(11;14) and +12 are common in ?
- B-CLL
- clinical difference between CML and CLL ?
- CML advances to acute
- Score for positive GAPA test ?
- < 20
- Philadelphia chromosome is in ?
- CML
- ?Most common luekemia in children ?
- ALL
- Most common leukemia in adults ?
- ALL
- Two disease causing kidney problems ?
- MM, HUS/TTP
- Ring sideroblasts can be found in ?
- MDS, Sideroblastic Anemia
- Micromegakaryocytes can be found in ?
- MDS
- Thrombocytopenia is when plt count is ?
- < 100G/L
- When can we find Dohle bodies ?
- May-Hegglin anomaly - Thrombocytopenia
- What is the most common cause of chronic thrombocytopenia ?
- ITP
- The antibodies in ITP are directed against?
- GPIIb-IIIb
- 2 immune, 3 non-immune mechanisms where we see thrombocytopenia
- immune : ITP, Neonatal. Nonimmune : TTP, DIC, HELLP
- difference in prevalance between HUS and TTP ?
- TTP - 20-50, women. HUS - children 4-6
- Large platelets can be seen in ?
- ITP, essential thrombocytosis, May-hegglin
- ABO gene is on which chromosome ?
- 9
- H- antigen is ? A ? B?
- H- L fucose, A- +GalNac, B-+Gal
- Bombay genotype ? which chromosome ?
- hh, 19
- 1 unit of RBCs increase Hct by ?
- 3%
- What is a good source of Fibrinogen?
- Cryo - not FFP
- Two highly immunogenic blood antigens ?
- D, Kell
- Two IgG blood antigens ?
- D, Kidd
- Two cases in which lutheran antigen is over expressed ?
- Carcinoma, sickle-cell anemia
- Which blood antigen is passively adsorbed onto blood cells from GI and is associated with H.Pylori infection ?
- Lewis
- What blood antigen is missing in Cord blood ?
- I
- Which blood antigen is associated with Plasmodium infection ?
- MSN
- Normal APPT time ? PT time ?
- APTT - 30 sec, PT - 10-12
- Which factors deficiencies increase both PTT and PT ?
- Factor V and prothrombin (Factor II)
- Where do you see Gumprech shadows ?
- CLL
- Which types of vWD are Quantitative ?
- 1, 3
- Which types of vWD are autosomal recessive ?
- 2N, 3
- In which vWD theré's a decrease in FVIII ?
- 1, 2N, 3
- Protein S inhibitor ?
- C4BP
- What decreases protein S ?
- SLE, Pregnancy - 2nd trimerster
- Glyvec is used for ?
- CML - Ph chromosome, BCR-ABL TK inhibitor
- Desfferoxamine is used for ?
- Thalassemias
- vWF is on which chromosome ?
- 12
- Two deficiencies that result in spontaneous abortions ?
- FXIII def, Afibrinogenemia, LA
- Bernard-soulier syndrome defect ?
- Missing or abnormal GP Ib-IX
- Defect in Glanzmann thrombosthenia is in ?
- Platelet aggregation
- Malignant diseases with frequent Thrombotic complications ?
- M3, Pancreas CC, Cerebral tumors
- What is the danger in a long standing central venous catheter ?
- Thrombosis
- Clinical criteria for APS ?
- Vascular thrombosis + Pregnancy morbidity
- Anti PL antibodies are usually against ?
- Beta2 glycoprotein I, and Prothrombin
- Clinical manifestation of LA ?
- In-vitro anticoagulant (bleeding), In vivo-Thrombosis !!!
- Why is only APTT prolonged in LA ?
- Demand for PL in intrinsic pathway only, hence only APTT
- Anti cardio lipin (ACA) antibodies can be of which isotypes ?
- IgG, IgM, IgA
- In which disease does a thrombotic phase precede bleeding ?
- Acute DIC & Large thrombus
- Test indicating activation of coagulation AND fibrinolysis in DIC ?
- D-Dimer
- 3 states when primary Hyperfibrinolysis occurs ?
- Prostate cancer, M3, Cirrhosis
- Leukemia with involvement of lymph nodes ?
- CLL
- 3 diseases with ischemia in various organs ?
- Sickle Cell anemia, DIC, TTP
- What is Mentzer index and what is it used for ?
- Testing for thalassemias, MCV/RBC < 13 is sick