leukemia and lymphoma
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- Lymphomas: Hodgkin's Versus NHL: Which one presents with Reed-Sternberg cells?
- Hodgkin's
- Lymphomas: Hodgkin's Versus NHL: Which one is associated with HIV and immunosuppression?
- NHL
- Lymphomas: Hodgkin's Versus NHL: Which one involves multiple, peripheral nodes, with common extranodal involvement?
- NHL
- Lymphomas: Hodgkin's Versus NHL: Which one is localized to a single group of nodes, with contiguous spread and rare extranodal involvement?
- HL
- Lymphomas: Hodgkin's Versus NHL: Which one presents with constitutional signs/symptoms: low-grade fever, night sweats, weight loss?
- HL (NHL has few signs/symptoms)
- Lymphomas: Hodgkin's Versus NHL: Which one presents with mediastinal lymphadenopathy?
- HL
- Lymphomas: Hodgkin's Versus NHL: Which one involves mostly the B cells (except lymphoblastic origin)?
- NHL
- Lymphomas: Hodgkin's Versus NHL: Which one has hypergammaglobulinemia?
- neither. Multiple Myeloma has hypergammaglobulinemia, where the excess B cells are in the resting state.
- Lymphomas: Hodgkin's Versus NHL: Which one has a 50% association with EBV?
- HL
- Lymphomas: Hodgkin's Versus NHL: Which one has bimodal age distribution?
- HL (NHL has peak incidence at 20-40 years old)
- Lymphomas: Hodgkin's Versus NHL: Which one has more common male presentation?
- HL
- Hodgkin's What factors denote a good prognosis?
- Increased lymphocytes, decreased RS cells.
- Hodgkin's Which HL type has the best prognosis?
- Nodular sclerosing (65-75%), which has least RS cells and lots of lymphocytes. Lymphocyte-predominant LH also has excellent prognosis.
- Hodgkin's Which HL type is the most common?
- Nodular sclerosing, affecting women more than men and primarily young adults.
- Hodgkin's What is the prognosis of mixed cellular HL?
- Intermediate. There are lots of lymphocytes but also lots of RS cells.
- Hodgkin's Which HL type has the worst prognosis?
- Lymphocyte-depleted, which affects older males with disseminated disease.
- Hodgkin's Which HL type has the most RS cells?
- Mixed cellular.
- Which NHL type has only B cells?
- Small Lymphocytic lymphoma, follicular lymphoma, Burkitt's
- Which NHL type has a mix of B cells and T cells?
- Diffuse large cell , occurring mostly in elderly but sometimes in children.
- Which NHL type has only T cells?
- Lymphoblastic Lymphoma, which has immature T cells. It is a very aggressive T-cell lymphoma.
- Which type is associated with a t(8;14) c-myc gene mutation?
- Burkitt's Lymphoma, occurring mostly in children. Has a high-grade "starry sky" appearance.
- Which type is associated with a t(14;18) mutation and overexpression of bcl-2?
- Follicular lymphoma, which is difficult to cure but has an indolent course.
- Which type is associated with EBV infection and is endemic in africa?
- Burkitt's
- Which is the most common childhood NHL?
- Lymphoblastic Lymphoma, which also presents with ALL and a mediastinal mass.
- Which is the most common adult version of NHL?
- Follicular lymphoma.
- Which NHL types occur in adults?
- Small lymphocytic lymphoma, follicular lymphoma.
- Which NHL types occur in children?
- Lymphoblastic lymphoma, Burkitt's lymphoma.
- Which NHL has a distribution of 80% adults and 20% children?
- Diffuse large cell lymphoma, which ALSO has an 80% B cells 20% T cell distribution.
- Which low-grade NHL type presents like CLL?
- Small Lymphocytic lymphoma.
- Leukemias: Peripheral and bone marrow characteristics
- Increased circulating leukocytes, bone marrow infiltrates of leukemic cells
- Leukemias: Consequences of marrrow failure
- Anemia (dec. RBC's), infections (dec. WBC's), hemorrhage (dec. platelets)
- Leukemias: Common organs of infiltration
- Liver, spleen, lymph nodes
- Leukemias: Characteristics of acute leukemias
- Blasts predominate, children or elderly, short or drastic course
- Leukemias: ALL characteristics (4)
- Lympholasts (pre-B or pre-T), children, most responsive to therapy, associated with Down's Syndrome
- Leukemias: AML characteristics (3)
- Myeloblasts, adults, auer rods
- Leukemias: Characteristics of chronic leukemias
- More mature cells, midlife age range, longer, less devastating course
- Leukemias: CLL characteristics - cells
- Lymphocytes, non-Ab producing B cells, increased smudge cells on peripheral blood smear
- Leukemias: CLL - population
- older adults
- Leukemias: CLL - presentation and course
- lymphadenopathy, hepatosplenomegaly, few sx., indolent course
- Leukemias: CLL is similar to?
- very similar to SLL (small lymphocytic lymphoma)
- Leukemias: CLL is associated with?
- warm antibody autoimmune hemolytic anemia
- Leukemias: CML cell characteristics
- Myeloid stem cells, increased neutrophils and metamyelocytes
- Leukemias: CML translocation?
- Ph Chromosome, t(9;22), bcr-abl
- Leukemias: CML acute complications?
- blast crisis (AML)
- what chromosomal translocation? CML
- Ph chromosome, t(9;22), bcr-abl
- what chromosomal translocation? Burkitt's lymphoma
- t(8;14), c-myc activation
- what chromosomal translocation? Follicular lymphomas
- t(14;18), bcl-2 activation
- what chromosomal translocation? AML- M3 type
- t(15;17), responsive to all-trans retinoic acid (ATRA)
- what chromosomal translocation? Ewing's sarcoma
- t(11;22)
- what chromosomal translocation? Mantle cell lymphoma
- t(11;14)