Lab Practicum Hematology slides
Terms
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what are the arrows pointing to? - platelet
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what are the arrows pointing to? -
giant platelets
Post spleenectomy is most common reason to find them
Also mb dt: May-Hegglin, leukemic myelofibrosis. -
what is the arrow pointing to? - segmented neutrophil
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usually only one seen in an RBC. DNA nuclear fragments.
Found in megaloblastic anemia, sickle-cell anemia, and post splenectomy. - Erythrocyte Howell-Jolly bodies:
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what is the arrow pointing to? - segmented neutrophils
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what is the arrowing pointing to? -
Band
The indentation is greater than 1/2 of the width of the hypothetical round nucleus. Opposite edges of nucleus become parallel giving horseshoe appearance. -
what is this? (arrow) - Band
- Neutrophilic bands constitute what percentage of WBCs in a normal peripheral blood smear?
- 1-5%
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which is the segmented neutrophil and which is the neutrophilic band? - the seg is on the left, the band on the right
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what are the pale blue inclusions in these cells' cytoplasm? - Dohle bodies, RER residual aggregates, but may increase in infectious dz, burns, cytotoxic chemicals, poisons.
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what type of WBCs are these? what causes them to look like this? -
Hypersegmented neutrophils (5 or more lobes)
Due to decreased B12 and Folate. -
I.D. these cells -
Peutz-Huet anomaly.
Hereditary anomaly characterized by hypolobulation of the nucleus of granulocytes. Pince-nez (bottom left). -
what is this WBC? -
neutrophilic metamyelocyte.
slightly indented nucleus, small pinkish-blue granules. Rarely seen in normal peripheral blood. -
what are these (arrows)? - lymphocytes
- what is the diameter of a lymphocyte?
- small: 7-10 micron range.
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what is this? - lymphocyte
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what are the arrows pointing to? - lymphocytes
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what is this? - lymphocyte (small, mature)
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what are the arrows pointing to? - lymphocytes
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what is this showing? - infectious mononucleosis
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what is this? - basophil
- these WBCs have grains of histamine and heparin, are NOT phagocytic and normally are less than 1 per 100 in peripheral cells
- basophil
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what is this? - neutrophil
- these prominent purplish and blue-black granules are associated with what?
- Toxic granulation: prominent purplish and blue-black granules, associated with severe infxn and other toxic states.
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what is this? - eosinophil
- how do you identify an eosinophil?
- Granulocytes characterized by acid stain eosin readily as pink/red granules.
- what make up eosinophilic granules? what are they toxic to?
- major basic protein & eosinophilic cationic protein. they are toxic to several parasites.
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what is going on here? - eosinophilia
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what is this? - monocyte
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what is this? - classic horse-shoe shaped monocyte
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what is this? - atypical monocyte
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what is this? - monocyte
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what's this? (arrow) - bone marrow: monoblast
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what are these cells and when are they seen? - Plasma cells. Maybe seen in young children, viral infx, herpes, EBV. Not seen in peripheral blood of healthy adult.
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what are the arrows pointing to? - macrocytes
- when will you see macrocytes?
- B12 and folate deficiencies
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what are the arrows pointing at? - macrocytes
- presence in the blood of erythrocytes with excessive variation in size
- anisocytosis
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identify these cells. - spherocytes
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identify these rbcs - hypochromic microcytic
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identify the rbc (arrow) - teardrop (dacrocyte)
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identify this cell - target cell (codocyte)
- when will you see a target cell?
- Common in thalassemia, sickle-cell anemia, Hb-S thalassemia, other hemoglobinopathies
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identify these cells - target cells
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identify these cells and when are they seen? - ovalocytes/elliptocytes. A few is normal, but small #’s are seen in: iron deficiency, thalassemia, other hemoglobinopathies
- thin elongated eythrocytes with a point at each end. Schistocytes of all types may be found. Found in Hb-S Thal and Sickle Cell.
- Drepanocytes
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identify these cells and when they are seen. - nucleated RBCs. Pernicious anemia & related B12-folic acid deficiency diseases. Usually see oval macrocytes and microcytes, and teardrops.
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identify these cells - sickle cells/drepanocytes