nl hemostasis
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- What factor causes arteriole vasodilation after injury?
- endothelin
- What does an activated platelet do?
- it changes shape and releases secretory granules
- What three factors prevent platelets from binding to uninjuried tissue?
- NO, ADPase, PGI2
- What two factors prevent coagulation?
- thrombomodulin, heparin like ptns
- Which factors does ptn C cleave?
- 5 and 8
- What produces von Willebrand factor?
- endothelial cells
- What produces tissue factor?
- endothelial cells
- What dx results from a defect in GpIb?
- Bernard-Soulier syndrome
- What is Bernard-soulier syndrome?
- a defectin GpIb
- What is von Willebrand Dx?
- defeciency of vWF
- What receptor binds fibrinogen?
- GpIIb-IIIa
- What happens without GpIIb-IIIa?
- glanzmann thrombastenia
- What opposes PGI2?
- TxA2
- What does the phospholipid complex do?
- help with binding of components of intrinsic cascade
- What is the Haneman factor?
- XII, the start of intrisic
- What happens to laminar flow with stasis or turbulance?
- brings platelets into contact with endothelium
- What is the function of a clot?
- to prevent excessive loss of blood from ruptured vessels
- What causes vasoconstriction initially?
- endothelin
- When do platelets become active?
- when exposed to endothelial collagen
- What do platelets release when activated?
- ADP, TxA2, serotonin
- What do ADP, TxA2, and serotonin do?
- recruit other platelets