pharm 4 2
Terms
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- OH rings on SPMs
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absence of one or both greatly increases oral effectiveness
- absence of both lets it cross BBB - alpha-carbon on SMPs
- enhances resistance to MAO and increases oral effectiveness and duration
- treating a SPM overdose
- acidificaion of urine will protinate SPMs, which are usually weak bases
- phenylephrine
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- A agonist
- decongestion of MMs
- hypotension
- paroxysmal atrial tachycardia
- mydriasis - epinephrine
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- A1 and B2 agonist
- vasoconstriction for local anesthesia
- control of hemorrhage
- hemostasis during surgery
- main drug for TIHR, esp w/ cardiac arrest and glaucoma - ephedrine
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- A agonist
- hypotension
- stress incontinence - albuterol
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- B2-receptor selective agonist
- used to treat asthma b/c it relaxes bronchial SM - salmeterol
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- B2-receptor selective agonist
- used to treat asthma b/c it relaxes bronchial SM - isoproterenol
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- B-receptor selective agonist
- used to treat asthma b/c it relaxes bronchial SM - isoproterenol trade names
- Isuprel
- acute anaphylactic Type I hypersensitivity reactions
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- antigens (bee venom, penicillin) evoke production of IgE that fixes to mast cells -> whole cascade
- vasodilation, vaso perm, edema, SM contration or relaxation can lead to death - EPI in TIHR
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- B2 receptor activation on mast cells increases cAMP levels and prevents degranulation
- A1 receptor activation supports blood pressure and prevents suffocation - dobutamine
- - acute heart failure in TIHR
- Dopamine use
- circulatory shock
- amphetamine
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- CNS Active Phenylethylamines
- attention deficit hyperactivity disorder - dobutamine trade name
- - Dobutrex