Coag factor nomenclature
Terms
undefined, object
copy deck
- Factor I
- Fibrinogen
- Factor II
- Prothrombin
- Factor III
- Tissue thromboplastin (Tissue Factor)
- Factor IV
- Ionized Calcium
- Factor V
- Labile factor
- Factor VI
- Doesn't exist!
- Factor VII
- Stabile factor
- Factor VIII
-
-Anti-hemophiliac factor AHF
-VIII:C (oagulant portion) - Factor IX
-
-Chrismas factor
-AHFb - Factor X
- Stuart-Prower factor
- Factor XI
- PTA --> plasma thromboplastin antecedent
- Factor XII
-
Hageman factor
-contact factor - Factor XIII
- Fibrin-stabilizing factor
- Fitzgerald factor
- HMWKininogen
- Fletcher factor
- prekallikrein
- Which factor is a Substrate factor?
- Fibrinogen
- Which factor is a Cofactor?
-
5-Labile factor
8-Factor VIII:C - Which factors are Enzymes?
-
Many:
IIa, VIIa, IXa, Xa, XIa, XIIa, prekallikrein - Which factors are serine proteases?
- Any of the enzymes that have been activated.
- Which factor is a transaminase?
- Factor XIII
- What are the 2 ways to classify coagulation factors?
-
1. By hemostatic function (above)
2. By physical properties - What are the 3 groups of factors based on phys. property?
-
1. Contact proteins
2. Prothrombin proteins
3. Fibrinogen/thrombin sensitive proteins. - What 4 factors are Contact proteins?
-
1. Prekallikrein
2. HMWK
3. Fx XII
4. Fx XI -
What types of hemostasis problems assoc. w/ Deficient
-F XI
-Hageman/Fletcher -
Factor XI = mild bleeding
Factors XII/Prekallikrein = thrombosis - What is in the prothrombin group?
-
Low-molecular wght proteins:
II, VII, IX, X
2, 7, 9, 10 - What's another name for the prothrombin group?
- Vit-K dependent group.
- What makes the Vit-K group unique?
- Gamma-carboxyglutamic acid - necessary for binding to platelets and Ca2+ binding.
- What acts as an antagonist to vitamin K?
- Warfarin - Coumadin.
- Why is the extrinsic pathway called extrinsic?
- B/c Tissue Factor (its phospholipid activates cascade) isnt normally in circulation.
- Where are the necess phospho-lipids for intrinsic pathway?
- In platelet membranes.