Psychopharm/comps
Terms
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- Depolarization
-
1. resting state is -70
2. NA+ into cell leads to positive charge=-60, cell gets excited (membrane altered) and fires
3. this is action potential=firing = NT release.(glutemate)
4. Excitatory - hyperpolarization
- 1. CL- goes into cell, inhibitory, cell goes fr0m -70 to -90, will not fires. GABA (barbs)
- Synapses kinds
- excitatory and inhibitory
- GABA
- inhibitory, in 75-90 percent of brain cells
- Glutemate
- Excitatory in 75-90 percent of brain cells
- 5HT
- Indole amine, from trypotophan makes you feel good, in 10 percent of brain cells
- NE and DA
- Catecholamines, from Tyrosine to L dopa to Dopa to DA to NE.
- ACh
- REsponsible for anticholinergic side effects caused by tricylics and antipsycotics (conventional)
- Reuptake
- NT is removed right after it exerts its effect on post synaptic membrane. Reuptake transport pump removes and deactinvates. Most common method of deactivating.
- SSRI's
- Prozac paxil, zoloft. (also lexapro and celexa)--sexual side effects, decrease orgasm decrease drive,(headache, sleepy, nervous)
- SNRI's
-
1. NRI--walbuterin/zyban-no sexual side effect
2. SNRI-Effexor, Remrone and SEzone (cymbalta)
In low doses affect 5ht, middle doses 5HT and NE high doses also DA. - Seraotonin-why not prescribed
- does not ex the Blood Brain Barrier.
- Prozac
- 5 day half life, not a big problem to miss one, arousing give to letghargic patient
- Zoloft
- 12 hour half life, can't miss a dose but can give drug holiday, arousing, give to lethargic patient
- Paxil
- Sedating, give to imsomniac patient