MDH staph
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- How do staph infections occur?
- lapse in host defense
- What does Ptn A do?
- binds to Fc region of Ab and protects bact from phagocytosis
- Which staph is coagulase positive?
- S. aureus
- What does staphulokinase do?
- lyses the formed fibrin clots
- Which staph have catalase?
- all
- What are cytolytic toxins used for?
- hemolysins--destroy RBC
- What is leukocidin?
- kills neutrophils
- What causes food poising?
- enterotoxins
- What are super antigens?
- bind to MCII on APC on the outside of the receptor---T cell activation and massive cytokine release
- Which enterotoxin is responsible for toxic shock syndrome?
- Enterotoxin F or Toxic Shock Syndrome Toxin 1
- What are exfaliating (ET-B) and epidermolytic (ET-A)?
- serine protease that cause scalded skin syndrome
- Which ET is chromosomal, thermalstable and inactivated by EDTA?
- ET-A
- Which ET is plasmid, thermalabile, and stable in EDTA?
- ET-B
- Which layer is affected by scalded skin syndrome?
- stratum granulosum
- Which sugar does S. aureus ferment?
- mannitol
- What is found in the walls of S. aureus?
- ptn A, ribital teichoic acid,
- What can S. aureus produce?
- alpha toxin and DNAse
- What is in the cell wall of staph that don't ferment mannitol nor contain ptn A?
- glycerol-teichoic acid
- Which drug should you use for superficial staph infection?
- clindamycin
- Which drugs do you use for deep staph infection?
- vancomycin, clindamycin
- Which drugs do you use to treat MRSA?
- vancomycin, trimethoprim-sulfamethoxazole
- What should you use to treat MRSA?
- cephalosporins
- Which gene is responsible for methicillin resistance?
- mecA gene complex
- Where does the genomic island reside?
- SCCmec
- What does mecA produce?
- penicillin binding ptn, PBP2A