I&I Hepatitis, HIV & opportunistic infections
Terms
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- family for HAV
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Picornavirus
+ss RNA, naked - family for HBV
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Hepadena
ONLY DNA
ico, enveloped, ds, circular - family for HCV
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Flavi
+ss RNA, enveloped, linear - family for HDV
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"delta"
+ss RNA, linear - family for HEV
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unclassified toga
+ss RNA, linear - presentation of HAV
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fecal/oral transmission
no chronic or carrier - presentation of HBV
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sexual or parenteral
chronic & oncogenic - presentation of HCV
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sexual or parenteral
chronic & oncogenic - presentation of HDV
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requires HBV to replicate
parenteral transmission - presentation of HEV
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fecal/oral
dangerous if pregnant - Implication of positive HBsAg
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surface antigen
active viremia - implication of positive HBcAg
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core antigen
found on capsid - implication of HBeAg
- envelope antigen
- implication of HBsAB
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protective after virus gone
(vacinated) - implication of HBcAB
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not protective
confirm infection during window period - Implication of HBeAB
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antibody to envelope
low risk of infectivity - Isosporiasis
- chronic intestinal infection in AIDs
- genes in HIV (& gene product)
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GAG- viral core proteins
Env- viral envelop prots
Pol- reverse transcriptase - proteins in HIV
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reverse transcriptase
p18 & p24 - mechanism of infection in HIV
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infects MPs via CCR5 (receptor)
MP acts as reservoir
decreased IL-1 secretion, less Ag presentation
high mutation rate
enters T's via CXCR4 binding to gp120 on virus (gp41 is anchor)
budding kills T cell
decrease response to Ag, less IL-2 & IFN gamma - initial response in HIV infection
- robust CD8 response initially