Block 1: Autonomics- Introduction
Terms
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- peptide with NE
- NPY
- peptide with ACh
- VIP
-
acetyl CoA + choline
--> acetylcholine - choline acetyltransferase (CAT)
-
acetylcholine
--> acetate + choline - acetylcholinesterase (AChE)
- Tyrosine to Epi
-
Tyrosine
DOPA
DA
NE
Epi - tyrosine to dopa
-
enzyme- tyrosine hydroxylase
use tetrahydrobiopterin
*Rate limiting step* - dopa to DA
-
enzyme- L-AAD
use- PP - DA to Epi
-
enzyme- Dopamine Beta Hydroxylase
use- ascorbate - NE to Epi
-
enzyme- PNMT (only in adrenal medulla and a few epi containing pathways in brain stem)
use- SAM - transported into sympathetic nerve
- tyrosine
-
transported into sympathetic nerve vesicles
inhibited by... -
DA
reserpine - NE release inhibited by
-
guanethidine
bretylium -
most important mechanism for terminatin of action of NE
blocked by... -
active reuptake into nerve terminal
cocaine
tricyclic antidepressants
anti-obesity - Where is MAO
- mito, especially in CNS
- where is COMT
- cytoplasm
-
transported into parasympathetic neuron
inhibited by -
choline
hemicholinium -
blocks ACh release from vesicles
forces ACh release from vesicles -
botulinum acting at VAMPS or SNAPS
black widow poison -
parasympathetic preganglionic fibers are
long/short
come from where?
ration of pre:post -
long
CN nuclei III, VII, IX, X
S2-S4
1:1 -
sympathetic preganglionic fibers are long/short
come from where?
ratio of pre:post
post-ganglionic fibers... -
short
T1-T12
L1-L5
1:20
unmyelinated!