Leukemias and Lymphomas
Terms
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- what are smudge cells characteristic of?
- CLL
- what are numerous small, mature monoclonal B cells characteristic of?
- CLL
- what is a/w lymph nodes that become painful upon consumption of alcohol?
- hodgkin lymphoma
- what are the 3 B symptoms?
-
weight loss of >10% in 6 mo.
night sweats
fever >38 degrees - what are Reed Sternberg cells characteristic of
- hodgkins disease
- 70% of what cancer are the "nodular sclerosing" type?
- hodgkins lymphoma
- in what lymphoma will you see eosinophilia in the blood?
- hodgkin's lymphoma
- describe the ann-arbour system of staging
-
I - one node area
II - two or more node areas on teh same side of the diaphragm
III - two or more node areas on differnet sides of the diaphragm
IIIs - nodes and spleen
IV - node areas as well as diffuse or disseminated disease
subscript E is added at the end to indicate extranodal expansion - which leukemias are a/w the philadelphia translocation
-
CML mainly
(although ALL can have it on occasion) - what is Gleevec used to tx?
- CML
- How does Gleevec work?
- It targets the bcr/abl abnormality, thus inhibiting tyrosine kinase activity which increases cell proliferation
- which is the luekemia where you need to give subdural prophylaxis?
- ALL b/c there are reserves in the CNS and the testes!
- which leukemia is a/w Down's syndrome?
- AML
- the presence of Auer rods indicates which leukemia?
- AML (it is the accumulation of myeloid granules) which distinguish it from ALL
- CLL is the same as which lyphoma?
- SLL - small lymphocytic lymphoma
- lymphoblastic lymphoma is the same as which leukemia?
- ALL
- for which leukemia is the treatment mainly palliative?
- CLL
- why do you use flow cytometry?
- to SUBTYPE a leukemia once the dx has been made
- what does CARLI stand for? And in what disease do you use this?
-
Use it for characteristics of MM.
C- hi calcium due to increased bone turnover
A- anemia (low RBCs)
R- renal failure
L - lytic bone lesions
I - infxns due to suppression of normal plasma f'n - investigation of the CSF is required in work up of which leukemia?
- ALL
- Staging for lymphomas involves what 3 procedures?
-
1. blood tests
2. bone marrow aspirate
3. CT scans of chest and abdomen - will lupus anticoagulant affect the PT or the PTT or both?
- only the PTT
- will heparin affect the PT, the PTT or both?
- the PTT only