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Drug therapy


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Aerosol anti-infectives, especially antibiotics should be administored with high flow rat Nebs the deliver how much flow?
10-12 L/min.
What are the 4 inhaled anti-infective agents?
1. Pentamidine (NebuPent)
2. Ribavirin (Virazole)
3. Tobramycin (TOBI)
4. Zanamivir ( Relenza)
What type of drug is Pentamidine?
is a antiprotozoal drug
Pentamidine prevents what?
Second line agent for Pneumocystis carinii PNA (PCP)
Where should PCP be administored?
In isolation and in negative pressure room.
What is Ribavirin?
is antiviral drug
Ribavirin is used for what disease?
Respiratory syncytial virus (RSV)
Adverse reactions with Ribavirin?
Bronchospasm, skin rash, eyelid erythema, and conjunctivitis.
What is Tobramycin is used for what patients?
Cystic Fibrosis in treatment of Pseudomonas aeruginosa
Possible advers reactions include for Tobramycin?
Auditory and vestibular damage and nephrotoxicity.
What drug is used in cases of influenza in adults and adolescents age 12 or older who have been symptomatic for less than two years.
Zanamivir (Relenza)
What is the function of Antitussive?
Suppress or inhibit coughing.
The major antitussives include:
1. Benzonatate(tesslaon perles)
2. Codeine
3. Dextromethorphan (suppress)
4. Hydrocodone
What is the effect of Benzonatate on the upper respiratory tract?
Anesthetizing stretch receptors throughout the bronchi, alveoli, and pleura.
What is the effects of Codeine, Dextromethorphan, and hydrocodone?
Suppress the cough reflex by direct action on the cough center in the medulla of the brain, thus lowering the cough thershold.

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