micro bio hx
Terms
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- oliver wendell holmes
- 1840: first contagious fever
- ignaz semmelweis
- 1861, hygeine in hospital to control fever
- lister
- 1870, disinfection/antiseptic, isolated agent
- Pasteur
- 1870, heat inactivation of microbes, discovered pathogens, devpt broth culture, developed attenuated vaccines
- Leeuwenhoek
- light microscope 1650
- Koch
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culture media/agar, postulates:
1. org in diseased animal
2. org isolated and grown in culture
3. org reproduces disease when re-inoculated
4. org. re-isolated from infected animal - Jenner
- late 1700 rediscovered variolization based on milkmaids/cowpox
- metchnikoff
- 1880s, cell immunity
- Ehrlich
- 1900s, magic bullets with antitoxin/antiserum to treat infection
- Florey/Chain
- built on Flemming's Penicillin discovery