BRS Pharm
Terms
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- streptogramins
- p450 inhibitor
- cosyntropin
- used for diagnosis of addison's disease
- interferon alpha
- produced by virally infected cells to prevent infection of adjacent cells
- bromocriptine
- inhibits PRL release
- celecoxib
- sulfa drug
- misoprostol
- eicosanoid preparation used for pts taking lots of NSAIDs
- nitroprusside
- increases cGMP in vascular smooth muscle
- ephedrine
- ma-huang
- sumatriptan
- causes vasoconstriction of cerebral vasculature
- ipratropium
- dry mouth side effect
- mercaptopurine (6-MP)
- activated by hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
- sulfonamides
- photosensitivity
- amantidine
- not effective against influenza B
- alteplase
- converts fibrin-bound plasminogen to plasmin
- pralidoxime
- antidote for anticholinesterases such as organophosphates
- tacrolimus
- used in transplant patients
- aminocaproic acid
- orally active inhibitor of plasminogen activation
- diphenoxylate
- suppress GI motility
- ibuprofen
- similar to aspirin, lacks antiplatelet effects
- flutamide
- androgen receptor antagonist
- thiopental
- ultra-short acting barbiturate used to induce surgical anesthesia
- ticarcillin
- used against enterobacter and pseudomonas
- clarithromycin
- macrolide
- leucovorin
- treats myelosuppression
- indomethacin
- potent NSAID used to close a PDA
- zidovudine
- chain terminator
- sumatriptan
- used for acute migraine and cluster headaches
- probucol
- prevents restenosis after angioplasty
- vincristine
- blocks microtubule polymerization and spindle formation
- acebutolol
- selective b1 blocker
- abciximab
- anticoagulant preventing restenosis after angioplasty
- polymyxin b
- only used topically
- cyclosporin
- binds to cyclophilins and inhibits the transcription of cytokine genes
- omeprazole
- H/K ATPase inhibitor
- zolpidem
- binds benzodiazepine receptors, antagonized by flumazenil
- sulbactam
- beta lactamase inhibitor
- amiodarone
- pulmonary fibrosis
- opioid overdose
- constricted pupils, clammy skin, nausea, drowsiness, resp depression
- ABVD
- adriamycin, bleomycin, vinblastine, dacarbazine
- penicillamine
- used to treat RA
- doxorubicin
- causes dilated cardiomyopathy
- raloxifene
- estrogen partial agonist
- sulfonylureas
- glyburide and glipizide
- pyrantel pamoate
- stimulates nicotinic receptors in nematodes
- filgrastim
- G-CSF
- leuprolide
- treatment for BPH and precocious puberty
- phenobarbital
- used to treat tonic-clonic seizures and crigler-najjar
- ropinirole
- forestalls the use of levodopa in parkinson's disease
- sumatriptan
- binds the serotonin 1D receptor
- phenytoin
- interferes with folate absorption
- acyclovir
- used to treat herpes
- flumazenil
- used for benzodiazepine overdose
- fluoroquinolones
- bad for cartilage
- MPTP
- destroys dopaminergic neurons of the nigrostriatal tract
- erythromycin
- GI irritation and acute cholestatic hepatitis
- succinylcholine
- nicotinic agonist that opens sodium channels
- sucralfate
- cannot be used with antacids or H2 blockers
- primaquine
- G6PDH
- cephalosporins
- bactericidal
- prednisone
- treatment for leukemia, lymphoma, RA, asthma
- busulfan
- pulmonary fibrosis
- streptogramins
- arthralgias and myalgias
- etoposide
- used to treat small cell carcinoma of the lung and prostate and testicular cancers
- rifampin
- imparts red-orange color to secretions
- adenosine
- short acting agent given IV for AV nodal arrhythmias
- aminocaproic acid
- used for acute bleeding in hemophilic patients
- infliximab
- binds and inhibits TNF-alpha
- n-acetylcysteine
- used for acetaminophen overdose
- meperidine
- causes increased ICP
- bethanechol
- muscarinic agonist
- procarbazine
- causes disulfiram-like reaction
- penicillins
- bactericidal
- phentolamine
- used in diagnosing pheochromocytoma
- adenosine
- causes cutaneous flushing
- carbamazepine
- inducer of p450
- erythromycin
- macrolide
- ivermectin
- onchocera volvulus and strongyloides stercoralis
- glitazones
- increase insulin sensitivity
- hydroxyurea
- used for sickle cell crisis
- tamoxifen
- increases risk of endometrial carcinoma
- vincristine
- microtubule inhibitor
- diphenhydramine
- causes drowsiness
- amiloride
- block sodium channels in the cortical collecting tubules
- nitroglycerin
- causes increase in cGMP in vascular smooth muscle
- ceftriaxone
- used for septic meningitis
- rifampin
- TB
- vancomycin
- used to treat c. difficile
- lysergic acid diethylamide
- hallucinogenic, nausea, weakness
- cisapride
- long QT
- ketamine
- should be given with benzodiazepines
- aspirin
- analgesic, antipyretic, antiplatelet, anti-inflammatory
- lamivudine
- inhibits reverse transcriptase of hepatitis B
- penicillins
- inhibits transpeptidation step in bacterial cell wall synthesis
- rifampin
- inducer of p450
- methotrexate
- inhibits DHFR
- amantadine
- prophylaxis against influenza A and rubella
- monteleukast
- LTD4 and LTE4 antagonist
- ampicillin
- extended spectrum penicillin used to treat gram negatives
- dynorphins
- bind kappa receptors
- ethambutol
- TB
- trastuzumab
- used for HER-2 positive breast cancer
- zidovudine
- given to prevent transmission of HIV to neonates
- theophylline
- inhibits conversion of cAMP to AMP
- lithium
- inhibits IP3 and DAG
- vasopressin
- used to treat esophageal varices
- daclizumab
- binds IL-2 receptor on activated T cells
- cisapride
- stimulates peristalsis by release of Ach from myenteric plexus
- ethosuxamide
- inhbits T-type calcium channels
- morphine
- binds mu receptors
- hydantoins
- erythema multiforme
- griseofulvin
- keratinized tissue
- chloroquine
- primary drug for acute malaria
- allopurinol
- suicide inhibition of xanthine oxidase
- abciximab
- antibody against glycoprotein 2b/3a receptor
- allopurinol
- slows production of uric acid, used to treat gout (and cancer)
- aspirin
- irreversible inhibitor of cyclooxygenase
- dantrolene
- used to treat malignant hyperthermia
- vancomycin
- used to treat MRSA
- etoposide
- G2 phase inhibitor
- acetaminophen
- massive hepatic necrosis
- cisplatin
- alkylating agent
- methanol
- causes damage by being converted to formaldehyde in the liver
- aminoglycosides
- ototoxic and nephrotoxic
- metronidazole
- activated by anaerobes and parasites
- entacapone
- inhibits conversion of levodopa to 3-0-methyldopa
- tacrolimus
- binds to the immunophilin FK-binding protein
- phencyclidine (pcp)
- nystagmus, hypertension, seizure
- colchicine
- microtubule inhibitor
- ethosuxamide
- stevens-johnson
- thalidomide
- potent immunosuppressant
- tranylcypromine
- MAOI
- selegiline
- inhibits degradation of dopamine in CNS, used with levodopa for parkinson's
- ribavirin
- guanosine analog
- gabapentin
- partial seizures
- acyclovir
- functions as a chain terminator when incorporated into viral DNA
- organophosphates
- anticholinesterases used in chemical warfare
- rofecoxib
- COX-2 inhibitor
- phenelzine
- MAOI
- anastrozole
- inhibits conversion of androstenedione to estrone
- valproic acid
- causes neural tube defects
- repaglinide
- binds potassium channels to facilitate insulin release
- sulfonylureas
- cause release of preformed insulin
- niacin
- increases HDL
- trimethoprim
- blocks DHFR
- atenolol
- selective b1 blocker
- penicillins
- erythema multiforme
- leuprolide
- GnRH agonist used to treat prostate cancer
- folic acid
- will correct anemia but not neuro sx associated with b12 deficiency
- disulfiram
- inhibits aldehyde dehydrogenase, causing an accumulation of acetaldehyde
- amphotericin B
- disrupts fungal membranes by binding ergosterol
- azithromycin
- macrolide
- bismuth subsalicylate
- used with metronidazole and tetracycline for PUD caused by h.pylori
- chloramphenicol
- aplastic anemia
- methylsergide
- used to prevent migraines
- sulfonamides
- stevens-johnson
- calcium carbonate
- hypercalcemic alkalosis
- niacin
- directly reduces secretion of VLDLs
- risperidone
- atypical antipsychotic with lots of extrapyramidal SE
- sulfinpyrazone
- acts simliarly to probenecid
- tetracycline
- photosensitivity
- PGE
- used to maintain a PDA in congenital heart disease
- diphenhydramine
- inhibit histamine binding to H1 receptors
- acarbose
- inhibits a-galactosidase
- marijuana
- lowers intraocular pressure in glaucoma
- hydroxyurea
- increases levels of HbF
- cefixime
- used to treat gonnorhea
- deferoxamine
- rapid infusion causes hypotensive shock
- HCTZ
- hypokalemia, alkalosis, hyperuricemia, hyperlipidemia
- leuprolide
- stimulates release of FSH and LH
- pyridostigmine
- used for tubocurarine toxicity
- colchicine
- leukocyte inhibitor used to treat attacks of gouty arthritis
- ethylene glycol
- causes metabolic acidosis and precipitation of oxalate crystals in the kidney
- n-acetylcysteine
- protects against fulminant hepatic failure
- mercaptopurine (6-MP)
- inhibits many enzymes involved in purine metabolism
- niacin
- causes cutaneous flushing
- thioridazine
- low potency dopamine receptor blocker
- lamotrigine
- stevens-johnson
- RhoGAM
- antibody to Rh(D) antigen that opsonizes
- griseofulvin
- binds tubulin
- cocaine
- inhibits catecholamine reuptake, resulting in cardiotox and hypertension
- vincristine
- used for lymphomas, wilms tumor, and choriocarinomas
- thiabendazole
- microtubule inhibitor
- MOPP
- mechlorethamine, oncovin, procarbazine, prednisone
- metronidazole
- bactericidal
- bleomycin
- causes strand breaks in DNA
- ritonavir
- inhibit protease in the HIV pol gene
- amiodarone
- corneal microdeposits
- aspirin
- predisposes to acute gastritis by inhibiting PGE in the stomach
- metronidazole
- interferes with nucleic acid synthesis
- bromocriptine
- used to treat hyperprolactinemia due to pituitary adenoma
- penicillamine
- used to treat wilson disease
- fluorouracil
- S phase antimetabolite
- neomycin
- used to treat hepatic encephalopathy
- anastrazole
- aromatase inhibitor
- dimercaprol
- chelates metals to keep them from damaging proteins
- nitrofurantoin
- can cause hemolysis in G6PDH deficient patients
- fluconazole
- inhibits formation of ergosterol
- reserpine
- antihypertensive agent that blocks the storage and release of catecholamines and serotonin from neurons
- cisplatin
- ototoxic and nephrotoxic
- statins
- may cause elevated liver enzymes
- anastrozole
- inhibitor of steroid synthesis
- metronidazole
- used to treat amebiasis, trichomoniasis, giariasis, and c. diff
- captopril
- functions at the collecting tubules
- nitroprusside
- stimulates guanyl cyclase
- daclizumab
- used for patients with renal allografts
- gold salts
- used in RA
- phenytoin
- class 1b antiarrhythmic
- digibind
- fab fragment antibody
- paclitaxel
- prevents mitotic spindle breakdown
- spironolactone
- aldosterone antagonist
- halothane
- massive hepatic necrosis
- flumazenil
- antagonizes benzodiazepines and zolpidem
- aztreonam
- used only with aminoglycosides against gram negative rods
- MAOI
- inhibits breakdown of amine neurotransmitters
- etanercept
- used in RA and inflammatory bowel disease
- acetazolamide
- inhibits carbonic anhydrase in the proximal convoluted tubule
- spironolactone
- functions at the collecting tubule
- fluoroquinolones
- bactericidal
- ketorolac
- parenteral NSAID
- glitazones
- stimulate PPAR-gamma receptor
- acyclovir
- activated by thymidine kinase of the virus it treats
- DES
- clear cell carcinoma of the vagina in daughters
- amantidine
- inhibits fusion of viral particles within endosome of the cell
- losartan
- functions at the collecting tubules
- gold salts
- nephrotoxic
- vancomycin
- bactericidal
- didanosine (ddI)
- dose-limiting pancreatitis
- methi, naf, diclox
- beta lactams
- ganciclovir
- SE: neutropenia, leukopenia, thrombocytopenia
- griseofulvin
- ringworm
- metoclopramide
- facilitates acetylcholine while blocking dopamine in the enteric nervous system
- fludrocortisone
- used in postadrenalectomy therapy
- carbapenem
- given with cliastatin
- pilocarpine
- muscarinic agonist
- fluoroquinolones
- bactericidal inhibitor of DNA gyrase
- thalidomide
- suppresses production of TNF-alpha
- ketoconazole
- gynecomastia
- carmustine
- alkylating agent that causes DNA cross-linking and strand breaks
- spironolactone
- gynecomastia
- selegiline
- inhibits MAO-B
- chloramphenicol
- gray baby syndrome in babies deficient in hepatic gluconosyltransferase
- repaglinide
- rapid onset sulfonylurea
- nitrofurantoin
- urinary antiseptic that requires acidification
- barbiturates
- erythema multiforme
- vancomycin
- causes cutaneous flushing
- valproic acid
- used to treat all kinds of seizures, as well as bipolar disorder
- neomycin
- prevents accumulation of nitrogenous microbial metabolites
- nitrous oxide
- has a high MAC
- amiodarone
- class III antiarrythmic
- calcium channel blockers
- causes cutaneous flushing
- phenobarbital
- increases the duration of chloride channel opening
- heparin
- activates AT3
- risperidone
- blocks D2 and serotonin-2 receptors
- cimetidine
- p450 inhibitor
- metformin
- biguanide compound
- sucralfate
- requires acidic environment to polymerize
- acetazolamide
- metabolic acidosis
- opioid withdrawal syndrome
- nausea, chills, sweats, lacrimation, cramps, rhinorrhea, yawning, piloerection, diarrhea, tremor
- isocarboxazid
- MAOI
- opiods
- causes biliary spasm
- valproic acid
- massive hepatic necrosis
- theophylline
- methylxanthine used for asthma
- fexofenadine
- nonsedating antihistaminic
- cimetidine
- gynecomastia
- paclitaxel
- interferes with anaphase
- ribavirin
- used to treat RSV
- flutamide
- used to antagonize residual androgens after orchiectomy
- nitrofurantoin
- can accumulate to toxic levels in patients with renal failure
- methicillin
- bulky R-group prevents degradation by penicillinase
- pyrazinamide
- TB
- streptokinase
- catalyzes conversion of plasminogen to plasmin
- methotrexate
- S phase inhibitor
- loratadine
- nonsedating antihistaminic
- succinylcholine
- muscle relaxant
- aztreonam
- b-lactamase resistant monobactam
- bromocriptine
- D2 agonist
- acyclovir
- guanosine analog
- cinchonism
- headache, vertigo, blurry vision, tinnitus
- streptogramins
- used to treat MRSA and VRE
- mescaline
- hallucinogenic, nausea, weakness
- mebendazole
- inhibits microtubule synthesis and glucose uptake by helminths
- tetracycline
- bacteriostatic drug
- fluconazole
- used to treat oral candidiasis
- quinine
- blocks DNA replication and RNA transcription in p. falciparum within RBCs
- bisphosphonates
- esophageal ulcerations
- phenoxybenzamine
- adrenergic antagonist (alpha receptors)
- fluorouracil
- causes myelosuppression
- phenobarbital
- binds GABA receptors
- MAO-B
- degrades dopamine
- allopurinol
- increases xanthine and hypoxanthine, which are less likely to form crystals than uric acid
- methylsergide
- causes fibroplasia of retroperitoneum and subendocardium
- isoniazid
- inhibits synthesis of mycolic acid
- bleomycin
- mixture of glycoproteins that produce free radicals upon binding DNA
- vasopression
- V1 and V2 agonist
- clindamycin
- treatment of bacteroides
- aluminum hydroxide
- constipating antacid
- erythromycin
- bacteriostatic inhibitor of 50s
- nifurtimox
- used to treat chagas disease
- ivermectin
- increases GABA transmission in the worm
- isoniazid
- SLE like syndrome
- paclitaxel
- microtubule inhibitor
- probucol
- acts as an antioxidant
- rituximab
- treatment of non-hodgkin lymphoma
- cephalosporins
- causes disulfiram-like reaction
- erythromycin
- p450 inhibitor
- misoprostol
- decreases gastric acid production, increases mucus production
- griseofulvin
- microtubule inhibitor
- interferon alpha
- used to treat CML, malignant myeloma, kaposi sarcoma, hairy cell leukemia
- theophylline
- inhibits phosphodiesterase
- statins
- may cause myositis
- mefloquine
- used for prophylaxis of p. falciparum due to low SE
- aspirin
- PGE inhibitor
- griseofulvin
- inducer of p450
- ibuprofen
- reversibly inhibits COX
- fluorouracil
- inhibits thymidylate synthase
- flutamide
- side effects include gynecomastia and libido changes
- cisplatin
- causes nephrotoxicity and acoustic nerve damage
- barbiturates
- inducer of p450
- benztropine
- CI are prostatic hyperplasia, GI obstruction, glaucoma
- ticlopidine
- platelet antiaggregant
- tazobactam
- beta lactamase inhibitor
- protamine sulfate
- reverses effects of heparin
- nafcillin
- bulky R-group prevents degradation by penicillinase
- salmeterol
- may cause tremors and arrhythmias
- vancomycin
- mildly ototoxic and nephrotoxic
- beclomethasone
- synthetic glucocorticoid that readily penetrates the airway mucosa, used for asthma
- fluorouracil
- used to treat colon cancer and basal cell carcinoma
- bleomycin
- G2 phase inhibitor
- isoniazid
- G6PDH
- troglitazone
- hepatotoxic
- minoxidil
- used topically bc of benefit of hypertrichosis
- abciximab
- prevents platelet activation
- clindamycin
- bacteriostatic at the 50s ribosome
- daunorubicin
- used to treat AML
- acetaminophen
- COX inhibitor which inhibits prostaglandin synthesis
- amphetamines
- indirect sympathomimetic MOA
- carmustine
- used to treat brain tumors, highly lipophilic nitrosourea drug
- dicloxacillin
- bulky R-group prevents degradation by penicillinase
- cyclophosphamide
- causes hemorrhagic cystitis
- zidovudine
- inhibits viral reverse transcriptase
- carvedilol
- used for CHF
- interferon alpha
- recombinantly produced cytokine
- octreotide
- used to treat carcinoid, gastrinoma, somatotropic pituitary adenoma
- ipecac syrup
- acts to stimulate chemoreceptor trigger zone of the medulla
- metformin
- increases peripheral glycolysis
- acetaminophen
- analgesic, antipyretic (but not anti-inflammatory)
- losartan
- CI in pregnancy
- methotrexate
- folic acid analog
- cholestyramine
- bind bile acids to prevent enterohepatic recycling
- succimer
- orally active metal chelator
- tamoxifen
- increases risk of endometrial cancer
- dantrolene
- decreases the release of calcium from the sarcoplasmic reticulum
- oseltamivir
- neuraminidase inhibitor that prevent viral spreading
- quinine
- used for malaria
- sulfonamides
- G6PDH
- aminocaproic acid
- inhibits fibrinolysis
- methimazole
- same as PTU but crosses placenta and enters breast milk
- danazol
- used for endometriosis and fibrocystic disease of the breast
- foscarnet
- inhibits viral DNA polymerase
- MAOI + SSRI
- serotonin syndrome
- bleomycin
- pulmonary fibrosis
- oseltamivir
- used against influenza a
- prazosin
- miosis
- zileutin
- inhibits leukotriene synthesis
- spironolactone
- potassium sparing diuretic
- meperidine
- causes relaxation of the sphincter of oddi
- tetracycline
- CI in pregnant women due to bone dysplasia and dental enamel defects
- quinine
- causes cinchonism
- bromocriptine
- ergot alkaloid
- enkephalin
- binds delta receptors
- sulfonylureas
- stimulate closure of potassium channels
- metoclopramide
- blocks D2 receptors in the area postrema
- methanol
- retinal damage, blindness, metabolic acidosis, coma
- TMP-SMX
- can cause megaloblastic anemia
- carvedilol
- nonselective beta blocker and alpha-1 blocker
- mifepristone
- blocks binding of progesterone to cytoplasmic receptors
- colchicine
- inhibits microtubule assembly, and therefore leukocyte migration and phagocytosis
- thioridazine
- side effects are retinal deposits, torsades, postural hypotension, sedation, CNS depression
- ganciclovir
- guanosine analog converted by CMV to triphosphorylated form
- naloxone
- used to treat opioid overdose
- probenecid
- inhibits secretion of weak acids
- nystatin
- disrupts fungal membrane permeability by binding to ergosterol
- TMP-SMX
- blocks folate synthesis
- zolpidem
- hypnotic drug that is not a benzodiazepine
- metoclopramide
- prokinetic agent used to block emesis
- statins
- may cause increased CK from skeletal muscle
- clavulanic acid
- beta lactamase inhibitor
- rituximab
- binds CD20 antigen on B cells
- captopril
- CI in pregnancy
- fluoroquinolones
- used for gram negative rods, some gram positives, and neisseria
- risperidone
- causes high sedation
- danazol
- inhibitor of p450
- reserpine
- enters the CNS and may cause suicidal depression and parkinsonian symptoms
- tamoxifen
- estrogen receptor partial antagonist
- foscarnet
- treats CMV
- lithium
- causes tremor, hypothyroidism, polydipsia, polyuria
- cyclophosphamide
- alkylating agent used to treat cancers
- loperamide
- suppress GI motility
- celecoxib
- COX-2 inhibitor
- ribavirin
- inibits steps in RNA synthesis
- detromethrophan
- depresses cough center in the medulla
- methadone
- treatment of opiod withdrawal
- prazosin
- first dose syncope
- flunitrazepam
- benzodiazepine used as a date rape drug
- leuprolide
- treatment for endometriosis
- sargramostim
- recombinant GM-CSF
- aminoglutethimide
- blocks conversion of cholesterol to pregnenolone
- EPO
- recombinant drug used for anemia
- capsaicin
- used topically for RA
- deferoxamine
- used to treat acute iron toxicity
- raloxifene
- does not increase the risk of endometrial cancer
- mebendazole
- microtubule inhibitor
- hydroxyurea
- inhbits DNA synthesis by blocking conversion of ribonucleotides to deoxyribonucleotides
- rofecoxib
- sulfa drug
- salicylates
- erythema multiforme
- ganciclovir
- requires phosphorylation by viral kinases to work
- cimetidine
- gynecomastia and galactorrhea
- thalidomide
- used to treat SLE, multiple myeloma, and leprosy
- methylphenidate
- stimulates the release of catecholamines
- tubocurarine
- nondepolarizing neuromuscular ganglionic blockers
- phenytoin
- inducer of p450
- mebendazole
- used to treat pinworms
- alprazolam
- intermediate-acting benzodiazepine used for panic disorder and phobias
- amiloride
- hyperkalemic metabolic acidosis
- isoniazid
- SE neuritis and hepatitis
- ipratropium
- antimuscarinic for COPD and asthma
- cimetidine
- p450 inhibitor
- metronidazole
- causes disulfiram-like reaction
- albuterol
- selective b2 agonist
- carbenicillin
- used against enterobacter and pseudomonas
- acetazolamide
- give to alkalinize the urine in aspirin toxicity
- penicillamine
- used to treat copper toxicity bc it is a chelator
- antimalarials
- erythema multiforme
- etoposide
- inhibits topoisomerase II
- capsaicin
- impairs release of substance P
- cyclosporin
- impairs T cell IL-2 production, used in transplant patients
- prednisone
- triggers apoptosis
- polymyxin b
- cationic detergent that disrupts bacterial membranes
- metoprolol
- selective b1 blocker
- loop diuretics
- ototoxic and nephrotoxic
- diphenhydramine
- used for allergies and motion sickness
- gold salts
- decreases lysosomal and macrophage function
- methylsergide
- blocks serotonin receptors
- ticlopidine
- interferes with binding of fibrin to Gp2b/3a receptor on platelets
- probenecid
- competes with uric acid for reabsorption in the proximal tubule
- trastuzumab
- binds to receptor tyrosine kinase Erb-B2 (HER-2)
- ketoconazole
- interfere with fungal cell wall synthesis
- magnesium hydroxide
- laxative antacid
- desmopressin
- selective V2 agonist
- psilocybin
- hallucinogenic, nausea, weakness
- phenytoin
- SLE like syndrome
- warfarin
- interferes with vitamin K dependent clotting factors
- streptomycin
- TB
- amantidine
- binds to M2 protein
- naloxone
- mu opioid receptor antagonist
- heparin
- inactivates thrombin
- benztropine
- antimuscarinic used to treat tremors and rigidity in parkinsons, but does nothing for bradykinesia
- carbachol
- nicotinic and muscarinic agonist
- fluconazole
- prophylaxis against cryptococcus neoformans
- amiodarone
- blocks sodium channels
- captopril
- inhibit breakdown of bradykinin
- ribavirin
- used to treat viral hemorrhagic fevers and hepatitis C
- etoposide
- causes double stranded breaks in DNA
- clomiphene
- blocks negative feedback at the pituitary
- vincristine
- M phase inhibitor
- calcium carbonate
- renal calculi
- doxorubicin
- intercalates in DNA to reduce replication and transcription
- polymyxin b
- causes neurotoxicity and acute tubular necrosis
- bleomycin
- can cause pulmonary fibrosis
- tetracycline
- inhibits 30s ribosome
- hydralazine
- SLE like syndrome
- cromolyn sodium
- stabilizes mast cell membrane
- nystatin
- used to treat oral candidiasis and diaper rash
- ketoconazole
- p450 inhibitor
- bacitraicin
- inhibits bacterial cell wall synthesis
- ethinyl estradiol/mestranol
- lowers risk of coronary disease, slows osteoporosis, ameliorates hot flashes
- misoprostol
- PGE analog
- probucol
- decreases HDL as well as LDL
- procainamide
- SLE like syndrome
- HRT
- increased risk of breast and ovarian cancer
- amiodarone
- photosensitivity
- praziquantel
- used for fluke and tapeworm infections
- scopolamine
- competitive cholinergic antagonist used for motion sickness
- pilocarpine
- treatment of glaucoma
- phenytoin
- SE are gingival hyperplasia, hirsutism, anemia, and birth defects
- aztreonam
- cannot be used against gram positives or anaerobic bacteria
- aminoglycosides
- bactericidal
- carbapenem
- used against gram positive cocci, gram negative rods, and anaerobes
- rifampin
- inhibits DNA-dependent RNA polymerase
- ganciclovir
- metabolized by viral transferases
- etanercept
- a fusion product of TNF-alpha receptor and Fc portion of antibody
- metoclopramide
- SE are sedation, diarrhea, extrapyramidal symptoms
- ondansetron
- serotonin-3 inhibitor that acts at the area postrema
- paclitaxel
- microtubule stabilizing agent
- chloroquine
- disrupts hemoglobin breakdown, with toxic accumulation of heme in RBC
- benztropine
- antimuscarinic
- dimercaprol
- used to treat heavy metal poisoning
- sulfamethoxazole
- blocks dihydropteroate synthase
- minoxidil
- direct-acting vasodilator
- TMP-SMX
- do not give to pts with G6PDH deficiency
- piperacillin
- used against enterobacter and pseudomonas
- nitroglycerin
- postural hypotension, headache, flushing
- propylthiouracil
- inhibits iodination step of thyroid hormone synthesis
- vancomycin
- rapid IV infusion causes red man syndrome
- nevirapine
- NNRTI used to treat HIV