bimm 120
Terms
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- eukaryotes vs prokaryotes
- eukaryotes have sterols in membrane but prokaryotes do not. EXCEPTION: mycoplasma & methanotrophs
- Prokaryotic SA
- SA/volume= 3.0 higher intake/outtake of molecules; grow faster
- Eukaryotic SA
- 1.5; have organelles that increase SA and volume, separate cellular contents
- Gaucher's Disease
- affects Jews storage disease mutation of lysosome gene defective in breaking down glycolipids
- peroxisomes
- metabolize FA and oxidize AA - use catalase to breakdown peroxide into water + O2
- Ubiquitin
- targets proteins to be broken down by proteosomes
- Svedburg
- determines ribosomal subunit size by centrifugation/fractionation
- Ribosomal subunits
- PRO: 70s cytoplasm EUK: 80s cytoplasm, 70s chloroplast, 55-70s mitochondria *MOST ABC TARGET 70S*
- BACTERIAL STUCTURE
- murein (peptidoglycan)= polysacc chains crosslinked together
- phosphomysin
- competitor to PEP from forming w/NAG to NAM
- Bacitracin
- inhibits release of P from bactoprenol for it to be recycled
- Cephalosporin
- targets enxyme transpeptidase to prevent crosslinking
- Vancomycin
- binds to peptide on D-Ala-D-Ala substrate; prevents transpeptidation
- D- cycloserine
- competitive inhibitor to enzymes that make terminal D-alanyl-D-alanine AAs of NAM pentapeptide