Headache Pharmacology
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- During a migraine attack, what happens to 5-HT levels in the blood and urine?
- bld levels dec, urine levels inc
- What happens to dorsal raphe nerve cells during sleep?
- they dec firing
- Which receptors are responsible for SMC relaxation, contraction of some vascular SMC?
- 5-HT1A,1B,1D
- Which receptors are responsible for vasoconstriction of most blood vessles, bronchoconstriction, contraction of GI SMC, platelet aggregation?
- 5-HT2
- What happens when 5HT1D are stimulated?
- neuronal inhibition of CNS
- What happens when 5-HT1B are stimulated?
- relaxation
- Where are 5-HT1 receptors located?
- cephalic vessels
- Which drugs are therapeutic for migraine?
- 5-HT1 selective drugs
- What are the contraindications for lithium?
- nephrogenic diabetes insipidus, thyroid disease, tremor
- What are the contraindications for propanolol?
- asthma, COPD, heart dx, bradycardia, DMII