Answers from Qbank HemeOnc
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- Idiopathic thrombocytopenic purpura - caused by..?
- Antibodies against platelets, splenic destruction of opsonized platelets, usually following a viral upper respiratory tract infection
- This enzyme is active during VDJ rearrangement in lymphocytes....marker of primitive cells in cancer?
- Terminal deoxynucleotidyl transferase
- Cytoplasmic mu chain expression indicates that a lymphocyte has undergone...?
- VDJ rearrangement
- Describe MCV, MCH, and MCHC of B12 anemia?
- High MCV, High MCH, and normal MCHC
- Target cells are most commonly seen in...?
- Thalassemia, hemoglobin C, and liver disease
- CLL is a disease of which age group?
- Older adults - 65
- Acute monocytic leukemia - what FAB classification?
- M5
- Hepatic chirrhosis is associated with which changes in the spleen?
- Thickened capsule and many small, scarred areas with fibrosis with hemosiderin and calcium deposition
- Which subtype of AML could lead to DIC? How?
- M3 - during tx as a cnosequence of release of granules (Auer rods) from cells in the promyelocytic line
- Crew haircut appearance of the skull is due to which conditions?
- Sickle cell anemia, thalassemia
- which translocations are associated with Burkitt lymphoma?
- 8;14, 8;22, 2;8
- Stage III Hodgkins with constitutional symptoms gets staged how..?
- Stage IIIB
- Describe serum levels of iron, ferritin, and transferrin in iron deficiency anemia?
- Serum iron and ferritin is decreased, while transferrin is increased
- Translocation seen in the follicular type of small cleaved cell (B cell) lymphoma?
- 14;18
- Reed Sternberg cells express which CDs?
- CD15 and CD30
- Lacunar cells are seen in which type of Hodgkin disease?
- Nodular sclerosing variant
- Which autoimmune disease is a significant cause of thyombocytopenia?
- SLE
- Acute promyelocytic leukemia is associated with which translocation?
- 15;17
- This disease causes purpura, fever, renal failure, MAHA, and microthrombi, frequently in young women..?
- Thrombotic thrombocytopenic purpura
- T or F? All lympgomas are monoclonal.
- True
- Defects in platelet adhesion are seen in which diseases?
- von Willebrand's and Bernard-Souliier
- T or F? Aspirin therapy interferes with secondary platelet aggregation.
- True
- This disease produces a self-limited granulomatous response in the draining lymph nodes...can be due to pets..?
- Bartonella henselae - cat-scratch disease
- Coadministration of warfarin and which antibiotic could produce pronounced anticoagulation and hematuria?
- Clarithromycin, norfloxacin
- T or F? In both thrombasthenia and vW disease, the platelet count will be normal, although platelet function is impaired.
- True
- This agent is primarily used to treat CLL and ovarian carcinoma?
- Chlorambucil
- What type of kidney stones would be expected in a patient undergoing tx for ALL?
- Uric acid kidney stones
- What cells predominate in a blood film of an infectious mono patient?
- Reactive T cells
- Most common cause of drug-induced thrombocytopenia?
- Heparin
- Hereditary spherocytosis is associated with a defect in..?
- Structural proteins such as spectrin and ankyrin
- Relapse in plasmodium infections are due to dormant forms of the organisms called...?
- Hypnozoites
- This medication can cause sharply demarcated, erythematous, and pupuric lesions, which can progress to large hemorrhagic bullae...
- Warfarin
- Characteristics of Bartonella henselae?
- Gram-negative bacillus
- What are D-dimers?
- Fibrin split products
- Lymphatic fluid from the lateral aspect of the dorsum of the foot drains to...?
- Lymph nodes in the popliteal fossa
- Clues: One week incubation period, Eastern seaboard, and intra-erythrocyte protoza..?
- Babesia microti
- Eosinophil granules contain which protein in their crystalline cores?
- Major basic protein
- Platelet count needs to be less than ......... before generalized bleeding usually occurs?
- 20,000/mm3
- Parvoviruses cause which three distinct syndromes?
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1. Fifth disease (erythema infectiosum)
2. Aplastic crisis in Sickle cell anemia, thalassemia, etc
3. Congenital infections - stillbirth, hydrops fetalis, anemia