Cell Bio Final
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- Some pharmaceutical companies are trying frantically to find inhibitors of telomerase. Such a drug could, in theory, be used to
- cure cancer
- The human female has 23 DIFFERENT chromosomes, whereas the human male has 24 DIFFERENT ones.
- 20%
- Human DNA contains 20% C on a molar basis. The percentage of G on a molar basis would be
- a. true
- Which of the following is an essential element of plasmids used as cloning vectors
- an origin of replication
- . If a cellular homogenate was subjected to differential centrifugation, which of the following would be expected to pellet first?
- nuclei
- The EXACT site of ribosomal RNA synthesis is
- nucleolus
- DNA is condensed as chromosomes for a very short time during interphase.
- FALSE
- The human genome is comprised of 23 pairs of chromosomes found in nearly every cell in the body. Each cell would have how many replication origins?
- >200
- When conducting research to determine which viral macromolecule actually entered an infected cell, 32P and 35S isotopes were used to grow the virus particles. The 35S would label
- protein
- Heterochromatin is
- transcriptionally inactive
- Tertiary structure of a protein. The interior has amino acids.
- hydrophobic
- The type of chromatography which could be usedto separate protein A (MW 36,000 daltons, pI 7.3) from protein B (MW 937,000 daltons, pI 7.3) upon this given data is
- molecular sieve
- Protein A and B were analyzed by 2D gel electrophoresis.The diagram on the right is the result. We can conclude that
- protein A is larger than B
- Regulation of protein activity by phosphorylation and dephosphorylation requires
- kinase
- Which level of protein structure is held together by hydrophobic interactions between non-polar side chains and hydrogen bonds between polar side chains?
- tertiary
- A compact and stable folded region of polypeptide usually related to a specific function is called a
- domain
- . A single protein may have both alpha helical and beta pleated sheet secondary structures
- TRUE
- Cys may play a role in
- a. primary structure b. secondary structure c. tertiary structure d. quarternary structure e. a, c and d
- The isomeric form of amino acids that living organisms are able to utilize is
- L
- The 6 common atoms in living systems: H, C, N, P, O and S each form a characteristic number of covalent bonds. For C, this number is
- 4
- . The synthesis of macromolecules by polymerization of monomeric subunits typically proceeds by
- dehyration
- The member of the pair at the right that H2C=CH2 H3C-CH3 is most reduced is
- B
- Which of the following reactions are energetically favorable
- sucrose--CO2+H2O
- Energetically favorable reactions are those that
- decrease the free energy of a system
- Which of the following features generally tend to increase the number of catalytic events an enzyme accomplishes per second?
- increased substrate concentration
- Competitive inhibitors
- don’t change the Vmax of a rxn
- The larger the binding energy between E and S, the larger the KM and the more likely they will be paired.
- FALSE
- . Activated carriers, such as ATP, acetyl-CoA, transfer chemical groups.
- TRUE
- . Fatty acids are
- amphipathic
- . Over the course of a day, in a normal individual the circulating levels of glucose vary around a mean of 90 mg/dL. What would this value be expressed as a molar concentration of glucose in blood, which is the way it is typically reported in the rest of
- 5x10 -3
- Radioisotopes differ from the normal, nonradioactive form of their elements by
- # neutrons
- Avagadro’s number 6.023 x 1023 indicates
- #molec in 1 mole of given sub
- All catabolic reactions involving macromolecules require input of
- water
- DNA is negatively charged at physiological pH. A protein Z binds to DNA through noncovalent ionic interactions involving lysines. What will be the effect of acetylation of the lysine side chains (see figure) in protein Z on the strength of this binding?
- ) It should decrease because the acetylated lysine no longer has a positive charge.
- Covalent bonds could be used in place of noncovalent bonds to mediate most of the biochemical reactions of macromolecules.
- F
- If oxidation occurs in a biochemical reaction, it is always accompanied by a reduction reaction.
- TRUE
- We humans use oxidation reactions to extract energy from food molecules.
- TR
- All of the following contain double membranes EXCEPT
- liposomes, cells, lysosomes
- Given what you know about the differences between procaryotic cells and eucaryotic cells, which of the following processes would not be to study in the model organism, E. coli.
- how mitochondria get distributed to cells during cell division
- Which of the following is not a characteristic or distinction of living organisms?
- high organ. Cmpd to non living
- Of the following items, the smallest is
- ribosome
- The specialized cell types in the body of a multicellular organism are different from each other chiefly because
- diff genes are switched on in diff cell types
- Which of the following cellular structures or compartments is found in both eukaryotes and prokaryotes.
- ribosome
- Which of the following statements about the basic chemistry of cells is TRUE?
- The genetic instructions in all cells are stored in DNA
- Mitochondria take in carbon dioxide and release oxygen
- FALSE
- Yeasts are
- eucaryotes
- Which membrane of mitochondria was derived from the cell membrane of the ancestral eucaryotic cell ?
- outer