Goodman intro to NS
Terms
-
Fight or flight
Rest and digest
-
Sympathetic
Parasympathetic
- ACh recptors.
-
Nicotinic: opens non-specific cationic channels
Muscarinic: acts via DAG/IP3 OR decrease cAMP to depolarize Vm
-
Alpha 1 receptor
-
Blood vessels, smooth muscle; excitation
More NE vs E
DAG/IP3
- Alpha 2 receptor
-
Nerve terminal; inhibit
Decrease cAMP
-
Autonomic NS
-
Involuntary
modulate ongoing activity
graded responses
excitatory and inhibitory
-
Beta 1 receptor
-
SA, AV nodes, ventricular muscle of heart; excitation
NE and E (more sensitive than Alpha)
Inc. cAMP [inactivate MLCK]
-
Beta 2 receptor
-
Blood vessels, smooth muscles
Relaxation
NE and E (increase sensitivity; better than Alpha)
Increase cAMP
-
Cholinergic transmission
-
post synaptic ganglia: nicotinic
effector tissues innervated by postgang. cholinergic: muscarinic receptors
- Clinical manipulation of adrenergic transmission
-
R agonists: mimic action (E)
R antagonist: block action (Beta blocker)
Manipulate limithing mechanisms: modulate responsiveness (MAO inhibitors)
-
Know the two major classes of receptors
-
Alpha 1 and 2
Beta 1 and 2
-
Location of ganglia for Sympathetic and parasympathetic
-
S: parallel to spinal cord.
P: close to, in tissue innervated
-
Noradrenergic transmission
-
Expands in diameter, vericosities.
Depolarization from AP, influx of Ca
Receptors alpha 1 and 2, beta 1 and 2
Autoreceptors; NE limits NE release
Reuptake or metabolism by MAO
- Peripheral NS includes:
-
Sensory systems
Somatic
Autonomic
-
Somatic NS
-
Voluntary
Required for activity
all or none
excitatory only