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Goodman intro to NS

Terms

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Fight or flight

Rest and digest 

Sympathetic

Parasympathetic 

ACh recptors.

Nicotinic: opens non-specific cationic channels

Muscarinic: acts via DAG/IP3 OR decrease cAMP to depolarize Vm 

Alpha 1 receptor  

Blood vessels, smooth muscle; excitation

More NE vs E

DAG/IP3 

Alpha 2 receptor

Nerve terminal; inhibit

Decrease cAMP 

Autonomic NS

Involuntary

modulate ongoing activity

graded responses

excitatory and inhibitory 

Beta 1 receptor

SA, AV nodes, ventricular muscle of heart; excitation

NE and E (more sensitive than Alpha)

Inc. cAMP [inactivate MLCK] 

Beta 2 receptor

Blood vessels, smooth muscles

Relaxation

NE and E (increase sensitivity; better than Alpha)

Increase cAMP 

Cholinergic transmission

post synaptic ganglia: nicotinic

effector tissues innervated by postgang. cholinergic: muscarinic receptors 

Clinical manipulation of adrenergic transmission

R agonists: mimic action (E)

R antagonist: block action (Beta blocker)

Manipulate limithing mechanisms: modulate responsiveness (MAO inhibitors) 

Know the two major classes of receptors

Alpha 1 and 2

Beta 1 and 2 

Location of ganglia for Sympathetic and parasympathetic

S: parallel to spinal cord.

P: close to, in tissue innervated 

Noradrenergic transmission

Expands in diameter, vericosities.

Depolarization from AP, influx of Ca

Receptors alpha 1 and 2, beta 1 and 2

Autoreceptors; NE limits NE release

Reuptake or metabolism by MAO 

Peripheral NS includes:

Sensory systems

Somatic

Autonomic 

Somatic NS

Voluntary

Required for activity

all or none

excitatory only 

Deck Info

14

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