M1-C2-L24 --> Overview of the Synaptic Transmission
Terms
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- T/F - Protein synthesis occurs inthe presynaptic area.
- False. In humans, proteins are made in the cell body.
- What are the 5 steps of neurotransmission?
-
1. Uptake/Synthesis
2. Storage
3. Release
4. Reception
5. Inactivation - What is the primary mechanism for NT release?
- Exocytosis
- What are the three ways in which inactivation of neurotransmission can occur?
-
1. Catabolism
2. Re-uptake
3. Uptake - Reuptake (uptake1) is dependent on what?
- Na+ dependent
- Uptake 2 is dependent on what?
- Na+ dependent
- Uptake 1 is specific for what?
- Neurons using THAT neurotransmitter
- What does it mean that the NT do "kiss and run."
- Vesicles doesn't release all the NT's.
- T/F - Chemical neurotransmitters are all or non mechanisms.
- False - they are graded
- Describe the affinity of peptidergic neurotransmission
- Greater than chemical NT
- Describe the inactivation of peptidergic NT's.
-
Degradation.
NO uptake - What is Dale's principle.
- All terminals of the same neuron release the same neurotransmitter(s).
- T/F - The distribution pattern of neuropeptides are random.
- False - Neither general nor random.
- T/F - Certain neuropeptides co-exist with other specific chemical NT's.
- False - no obvious rules determining which neuropeptides coexist with which other transmitters.
- T/F - Peptidergic NT's have very specific behavioral and physiological effects.
- True