chpt 7 2
Terms
undefined, object
copy deck
- similarities of MHC 1 and 2 binding cleft
- both have two alpha helices on sides and beta sheet at base of cleft
- 3 differences of binding regions of mhc 1 and 2
-
1. closed end vs. open
2. 9 res vs. 15
3. deep vs. constant elevation
conserved vs. motif - where variation among polymorphic alleles in human genome of HLA are clustered:
- around peptide binding domains (a1/a/2 in MHC1, A1/B1 in MHC2
- result of CLOSELY LINKED MHC loci:
- 1/4 chance siblings will be histocompatible
- relative risk
-
freq of allele in paitent/freq of allele in control population..
higher the risk of disease - patient will be more susceptible to it - why are tcells mhc restricted?
- only those that recognize self mhc can survive positive selection in the thymus
- site of synthesis/processing of MHC1 and 2
- RER/golgi apparatus
- if virus is dead, which pathway of Ag degradation will NOT WORK
- endogenous
- ubiquitin signals
- proteolysis of endogenous Ag.
-
function of
hla-dm
hla-do -
DO says DON'T; it inhibits removal of CLIP from MHC and prevents Ag binding
DM says DO: it removes clip so antigen can bind MHC2 - WHAT ARE LIPIDS PRESENTED ON
- Class 1 nonclassical CD1