Coag instruments
Terms
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- What is coagulation instrumentation based on?
- detection of an endpoint in the coag cascade when a clot forms.
- When are the 2 most common times you would use coag?
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1. To monitor anticoag therapy
2. before a surgical procedure - what are 2 common coag tests?
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PT: prothrombin time
APTT: actvtd ptl thromboplastin time
also Factor assays - what is PT?
- the time it takes for a clot to form.
- What are 3 ways to measure coagulation?
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1. Manual
2. Mechanical
3. Optical - What is the manual method that we'll use next year called?
- Fibrometer
- What's the principle of the fibrinometer?
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1. Automatic pipetter shoots sample into cup, time starts.
2. Heater starts and 1 probe agitates. 1 probe stationary.
3. When clot forms, agitation stops; current flows; time stops. Endpoint detected! - What's an advantage/disadvantage of the mechanical method?
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-More precise btwn techs
-More cumbersome/frustrating method. - What are some different photometric coag methods?
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1. Light scatter optical
2. Turbidometric
3. Viscosity
4. Absorbance /or fluorescence. - What's a chromogenic assay based on?
- the fact that a chromophore when bound to pna doesn't shine, but when a coag factor cleaves it, it does shine. allows for factor assays.