FA Biochemistry Familial Dyslipidemias
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- Question
- Answer
- What is Type I Familial Dyslipidemia?
- hyperchylomicronemia
- What is Type IIa Familial Dyslipidemia?
- hypercholesterolemia
- What is Type IIb Familial Dyslipidemia?
- combined hyperlipidemia
- What is Type III Familial Dyslipidemia?
- dysbetalipoproteinemia
- What is Type IV Familial Dyslipidemia?
- hypertriglyceridemia
- What is Type V Familial Dyslipidemia?
- mixed hypertriglyceridemia
- What is the INHERITANCE of Type IIa Familial dyslipidemia? (hypercholesterolemia)
- autosomal dominant
- What is INCREASED in Type I Familial Dyslipidemia?
- chylomicrons
- What is INCREASED in Type IIa Familial Dyslipidemia (hypercholesterolemia)?
- LDL
- What is INCREASED in Type Iib Familial Dyslipidemia (combined hyperlipidemia)?
- LDL, VDL
- What is INCREASED in Type III Familial Dyslipidemia (dysbetalipoproteinemia)?
- IDL, VLDL
- What is INCREASED in Type IV Familial Dyslipidemia (hypertriglyceridemia)?
- VLDL
- What is INCREASED in Type V Familial Dyslipidemia (mixed hypertriglyceridemia)?
- VLDL, chylomicrons
- Type I hyperchylomicronemia ELEVATED BLOOD LEVELS?
- TG, cholesterol
- Type IIa hypercholesterolemia ELEVATED BLOOD LEVELS?
- cholesterol
- Type IIb combined hyperlipidemia ELEVATED BLOOD LEVELS?
- TG, cholesterol
- Type III dysbetalipoproteinemia ELEVATED BLOOD LEVELS?
- TG, cholesterol
- Type IV hypertriglyceridemia ELEVATED BLOOD LEVELS?
- TG
- Type V mixed hypertriglyceridemia ELEVATED BLOOD LEVELS?
- TG, cholesterol
- Type I hyperchylomicronemia PATHOPHYSIOLOGY?
- Lipoprotein lipase deficiency, or altered apolipoprotein C-II (co-factor for lipoprotein lipase)
- Type IIa hypercholesterolemia PATHOPHYSIOLOGY?
- DECREASE LDL receptors
- Type IIb combined hyperlipidemia PATHOPHYSIOLOGY?
- hepatic OVERPRODUCTION of VLDL
- Type III dysbetalipoproteinemia PATHOPHYSIOLOGY?
- ALTERED apolipoprotein E
- Type IV hypertriglyceridemia PATHOPHYSIOLOGY?
- hepatic OVERPRODUCTION of VLDL
- Type V mixed hypertriglyceridemia PATHOPHYSIOLOGY?
- INCREASE production/DECREASE clearance of VLDL and chylomicrons