Cholinergic Pharmacology
Terms
-
carbachol
bethenechol
-
M agonist
carbachol is for OAG
-
galantamine
donepezil
-
noncovalent anti-AChE
treat alzheimer's
-
ipratoprium
tiotoprium
-
M antagonist
tx COPD, chronic bronchitis, (Asthma)
-
tolterodine
oxybutinin
-
M antagonist
tx overactive bladder
- atropine
-
M antagonist
tx bradycardia, AV block, GI hypermotility,
AChEi toxicity - D-tubocurarine
-
competitive Nm antagonist
seldom used due to s/e's
HM release from mast cells
ganglionic block
- echothiophate
-
phosphorylating anti-AChE
tx refractory OAG
contraindicated in Narrow Angle Glaucoma
- edrophonium
-
noncovalent anti-AChE
short half-life
diagnose MG
reverse NMJ competitive blockade
- homatropine
-
M antagonist
cycloplegia, mydriasis
-
malathion
-
insecticide / phosphorylating anti-AChE
admin as prodrug P=S -> P=O via p450 insects convert better than mammal
-
methacholine
-
M agonist
metabolized by AChE
-
muscarine
-
M agonist
- neostigmine
-
carbamolating anti-AChE
tx MG
reverse NMJ competitive blockade
- physostigmine
-
carbamolating anti-AChE
tx OAG
reverse atropine overdose
- pilocarpine
-
M agonist
tx OAG, xerostomia
- propantheline
-
M antagonist
NOT indicated for ulcers
- pyridostigmine
-
carbamolating anti-AChE
tx MG
reverse NMJ competitive blockade
prophy in military against nerve gas
- rivastigmine
-
carbamolating anti-AChE
tx alzheimer's
- scopalamine
-
M antagonist
anti-motion sickness
- soman
-
nerve gas / phosphorylating anti-AChE
rapid aging
- succinylcholine
-
depolarizing Nm antagonist
inactivates Na channel
short duration
resistant to AChE (anti-AChE augments block) degrade - Symptoms of AChE inhibitor toxicity
-
Diarrhea
Urination
Miosis
Muscle Weakness
Bradycardia
Brochoconstriction
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Lacrimati